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    MSC-AS1 MSC antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100132891, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MSC-AS1provided by HGNC
    Official Full Name
    MSC antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:48724
    See related
    Ensembl:ENSG00000235531 AllianceGenome:HGNC:48724
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAT1
    Expression
    Ubiquitous expression in urinary bladder (RPKM 4.5), gall bladder (RPKM 4.1) and 24 other tissues See more
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    Genomic context

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    See MSC-AS1 in Genome Data Viewer
    Location:
    8q13.3-q21.11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (71843123..72056312)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (72278328..72491399)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (72755358..72968547)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986890 Neighboring gene U8 small nucleolar RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27517 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:72742776-72743975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:72753440-72754300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19278 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19280 Neighboring gene musculin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27524 Neighboring gene ribosomal protein S20 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27525 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:72945660-72946859 Neighboring gene transient receptor potential cation channel subfamily A member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:72987624-72988195 Neighboring gene uncharacterized LOC124901962 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:73064806-73065399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27527 Neighboring gene transient receptor potential cation channel subfamily A member 2, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chromosomal instability-associated MAT1 lncRNA insulates MLL1-guided histone methylation and accelerates tumorigenesis. Pan H, et al. Cell Rep, 2022 Dec 13. PMID 36516779
    2. Expression of lncRNA MSC-AS1 in hepatocellular carcinoma cell lines and its effect on proliferation, apoptosis, and migration. Kou X, et al. Turk J Gastroenterol, 2020 Dec. PMID 33625998, Free PMC Article
    3. Long noncoding RNA MSC-AS1 promotes hepatocellular carcinoma oncogenesis via inducing the expression of phosphoglycerate kinase 1. Cao C, et al. Cancer Med, 2020 Jul. PMID 32489020, Free PMC Article
    4. lncRNA MSC-AS1 activates Wnt/β-catenin signaling pathway to modulate cell proliferation and migration in kidney renal clear cell carcinoma via miR-3924/WNT5A. Hu Z, et al. J Cell Biochem, 2020 Oct. PMID 31916281
    5. Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients. Luo J, et al. J Int Med Res, 2021 Oct. PMID 34617815, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis.
      Title: LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis.
    2. Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients.
      Title: Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients.
    3. Expression of lncRNA MSC-AS1 in hepatocellular carcinoma cell lines and its effect on proliferation, apoptosis, and migration.
      Title: Expression of lncRNA MSC-AS1 in hepatocellular carcinoma cell lines and its effect on proliferation, apoptosis, and migration.
    4. Long non-coding RNA MSC-AS1 facilitates the proliferation and glycolysis of gastric cancer cells by regulating PFKFB3 expression.
      Title: Long non-coding RNA MSC-AS1 facilitates the proliferation and glycolysis of gastric cancer cells by regulating PFKFB3 expression.
    5. LncRNA MSC-AS1 facilitates lung adenocarcinoma through sponging miR-33b-5p to up-regulate GPAM.
      Title: LncRNA MSC-AS1 facilitates lung adenocarcinoma through sponging miR-33b-5p to up-regulate GPAM.
    6. MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway.
      Title: MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway.
    7. MSC-AS1 induced cell growth and inflammatory mediators secretion through sponging miR-142-5p/DDX5 in gastric carcinoma.
      Title: MSC-AS1 induced cell growth and inflammatory mediators secretion through sponging miR-142-5p/DDX5 in gastric carcinoma.
    8. lncRNA MSC-AS1 activates Wnt/beta-catenin signaling pathway to modulate cell proliferation and migration in kidney renal clear cell carcinoma via miR-3924/WNT5A.
      Title: lncRNA MSC-AS1 activates Wnt/β-catenin signaling pathway to modulate cell proliferation and migration in kidney renal clear cell carcinoma via miR-3924/WNT5A.
    9. Downregulated Long Non-Coding RNA MSC-AS1 Inhibits Osteosarcoma Progression and Increases Sensitivity to Cisplatin by Binding to MicroRNA-142.
      Title: Downregulated Long Non-Coding RNA MSC-AS1 Inhibits Osteosarcoma Progression and Increases Sensitivity to Cisplatin by Binding to MicroRNA-142.
    10. we demonstrated that MSC-AS1/miR-29b-3p axis modulates the cell proliferation and GEM-induced cell apoptosis in PDAC cell lines through CDK14. We provided a novel experimental basis for PDAC treatment from the perspective of lncRNA-miRNA-mRNA network.
      Title: The role of lncRNA MSC-AS1/miR-29b-3p axis-mediated CDK14 modulation in pancreatic cancer proliferation and Gemcitabine-induced apoptosis.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • MSC-antisense-transcript 1

    Clone Names

    • FLJ53548

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_033651.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an inferred alternate promoter and omits an exon, resulting in a shorter transcript compared to variant 1.
      Source sequence(s)
      AC016057, BF171746, BQ332273, DB161440
      Related
      ENST00000457356.9

    2. NR_033652.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC016057, AK304427

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      71843123..72056312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      72278328..72491399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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