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    PEP1 type I sorting receptor [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEP1
    Official Full Name
    type I sorting receptor
    Primary source
    SGD:S000000113
    Locus tag
    YBL017C
    See related
    AllianceGenome:SGD:S000000113; FungiDB:YBL017C; VEuPathDB:YBL017C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPS10; VPT1
    Summary
    Enables signal sequence binding activity. Involved in mitophagy; pexophagy; and protein targeting to vacuole. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEP1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (186844..191583, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA-(apurinic or apyrimidinic site) lyase APN2 Neighboring gene ribonuclease P Neighboring gene mitogen-activated serine/threonine-protein kinase FUS3 Neighboring gene acetyl-CoA hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ligand recognition and domain structure of Vps10p, a vacuolar protein sorting receptor in Saccharomyces cerevisiae. Jørgensen MU, et al. Eur J Biochem, 1999 Mar. PMID 10095782
    2. The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Cereghino JL, et al. Mol Biol Cell, 1995 Sep. PMID 8534908, Free PMC Article
    3. The yeast Vps10p cytoplasmic tail mediates lysosomal sorting in mammalian cells and interacts with human GGAs. Dennes A, et al. J Biol Chem, 2002 Apr 5. PMID 11801606
    4. The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Marcusson EG, et al. Cell, 1994 May 20. PMID 8187177
    5. Decreased proteinase A excretion by strengthening its vacuolar sorting and weakening its constitutive secretion in Saccharomyces cerevisiae. Chen Y, et al. J Ind Microbiol Biotechnol, 2017 Jan. PMID 27866332

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myosin V-mediated transport of Snc1 and Vps10 toward the trans-Golgi network.
      Title: Myosin V-mediated transport of Snc1 and Vps10 toward the trans-Golgi network.
    2. Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner.
      Title: Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signal sequence binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type I sorting receptor
    NP_009536.1
    • Type I transmembrane sorting receptor for multiple vacuolar hydrolases; plays role in post-ER quality control in the Golgi, involved in protein targeting from the endoplasmic reticulum to the vacuole for degradation; cycles between late-Golgi and prevacuolar endosome-like compartments; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      186844..191583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178257.1 → NP_009536.1  TPA: type I sorting receptor [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZKT1, D6VPY3, P32319
      UniProtKB/TrEMBL
      N1P9R4
      Conserved Domains (1) summary
      smart00602
      Location:752 → 1379
      VPS10; VPS10 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32319.1

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