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    ANP1 Anp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ANP1
    Official Full Name
    Anp1p
    Primary source
    SGD:S000000762
    Locus tag
    YEL036C
    See related
    AllianceGenome:SGD:S000000762; FungiDB:YEL036C; VEuPathDB:YEL036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GEM3; MNN8
    Summary
    Contributes to alpha-1,6-mannosyltransferase activity. Involved in protein N-linked glycosylation. Located in Golgi cis cisterna. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ANP1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (83050..84552, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative acireductone synthase UTR4 Neighboring gene Rad23p Neighboring gene Utr5p Neighboring gene translation elongation factor eIF-5A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An extensive deletion causing overproduction of yeast iso-2-cytochrome c. McKnight GL, et al. Cell, 1981 Aug. PMID 6269746
    2. Protein glycosylation defects in the Saccharomyces cerevisiae mnn7 mutant class. Support for the stop signal proposed for regulation of outer chain elongation. Ballou L, et al. J Biol Chem, 1989 Jul 15. PMID 2663843
    3. Yeast invertase polymorphism is correlated with variable states of oligosaccharide chain phosphorylation. Frevert J, et al. Proc Natl Acad Sci U S A, 1982 Oct. PMID 6755465, Free PMC Article
    4. Requirement of the Saccharomyces cerevisiae APN1 gene for the repair of mitochondrial DNA alkylation damage. Acevedo-Torres K, et al. Environ Mol Mutagen, 2009 May. PMID 19197988, Free PMC Article
    5. The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway. Chapman RE, et al. EMBO J, 1994 Oct 17. PMID 7957057, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of APN1 has a stronger phenotype in mitochondrial ucDNA repair than in nuclear DNA.
      Title: Requirement of the Saccharomyces cerevisiae APN1 gene for the repair of mitochondrial DNA alkylation damage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to alpha-1,6-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to alpha-1,6-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mannan polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mannan polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Anp1p
    NP_010878.1
    • Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      83050..84552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178851.1 → NP_010878.1  TPA: Anp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010878.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLL3, P32629
      UniProtKB/TrEMBL
      A6ZQR4, B3LRY1, C7GKD9, G2WCJ7, N1P7C1
      Conserved Domains (1) summary
      pfam03452
      Location:61 → 323
      Anp1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32629.3

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