BRR6 Brr6p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: BRR6
Official Full Name: Brr6p
Primary source: SGD:S000003216
Locus tag: YGL247W
See related: AllianceGenome:SGD:S000003216; FungiDB:YGL247W; VEuPathDB:YGL247W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables chromatin binding activity. Involved in lipid homeostasis; nuclear envelope organization; and regulation of transcription by RNA polymerase II. Located in cell periphery and endoplasmic reticulum. Is active in nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

A short perinuclear amphipathic alpha-helix in Apq12 promotes nuclear pore complex biogenesis.
Title: A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis.
Brr6 and Brl1 transiently associate with nuclear pore complex (NPC) assembly sites where they promote NPC biogenesis.
Title: Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis.
Brl1p functions for nuclear export as a complex with Brr6p
Title: Brl1p -- a novel nuclear envelope protein required for nuclear transport.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IEA Inferred from Electronic Annotation more info
involved_in nuclear envelope organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_011267.1

Essential nuclear envelope integral membrane protein; interacts with chromatin, helping to maintain normal chromatin architecture and transcriptional regulation of certain loci at the nuclear envelope; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; homologous to Brl1p

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The following sections contain reference sequences that belong to a specific genome build. Explain