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    SCY1 Scy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCY1
    Official Full Name
    Scy1p
    Primary source
    SGD:S000003051
    Locus tag
    YGL083W
    See related
    AllianceGenome:SGD:S000003051; FungiDB:YGL083W; VEuPathDB:YGL083W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-4. Orthologous to human SCYL2 (SCY1 like pseudokinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SCY1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (353058..355472)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Lcl3p Neighboring gene O-acyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene dosage adaptations to mtDNA depletion and mitochondrial protein stress in budding yeast. McNamara JT, et al. G3 (Bethesda), 2024 Feb 7. PMID 38126114, Free PMC Article
    2. Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae. Sullivan DP, et al. Eukaryot Cell, 2009 Feb. PMID 19060182, Free PMC Article
    3. A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance. Michel S, et al. BMC Genet, 2015 Feb 11. PMID 25887987, Free PMC Article
    4. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article
    5. Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes. Lamb NA, et al. Genetics, 2022 Jul 30. PMID 35686905, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Scy1p
    NP_011432.1
    • Putative kinase; suppressor of GTPase mutant; dosage-sensitive modulator of mitochondrial DNA (mtDNA) homeostasis; localizes to the mitochondrial matrix, and to the cytosol and clathrin-coated vesicles in HTP studies; similar to bovine rhodopsin kinase; may have a role in intracellular sterol transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      353058..355472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180948.1 → NP_011432.1  TPA: Scy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011432.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU61, P53009
      UniProtKB/TrEMBL
      B5VIP1, N1P1V4
      Conserved Domains (1) summary
      cd14011
      Location:18 → 326
      PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53009.1

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