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    ROF1 Rof1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ROF1
    Official Full Name
    Rof1p
    Primary source
    SGD:S000001220
    Locus tag
    YHR177W
    See related
    AllianceGenome:SGD:S000001220; FungiDB:YHR177W; VEuPathDB:YHR177W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ROF1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (456591..457952)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene N,N-dimethylaniline monooxygenase Neighboring gene Stb5p Neighboring gene NADPH dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Lohse MB, et al. Proc Natl Acad Sci U S A, 2014 Jul 22. PMID 24994900, Free PMC Article
    2. High-Copy Overexpression Screening Reveals PDR5 as the Main Doxorubicin Resistance Gene in Yeast. Demir AB, et al. PLoS One, 2015. PMID 26690737, Free PMC Article
    3. Transcriptional Profiling of Biofilm Regulators Identified by an Overexpression Screen in Saccharomyces cerevisiae. Cromie GA, et al. G3 (Bethesda), 2017 Aug 7. PMID 28673928, Free PMC Article
    4. Efficient construction of homozygous diploid strains identifies genes required for the hyper-filamentous phenotype in Saccharomyces cerevisiae. Furukawa K, et al. PLoS One, 2011. PMID 22039512, Free PMC Article
    5. Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae. Niu W, et al. PLoS Genet, 2008 Jul 11. PMID 18617996, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rof1p
    NP_012047.1
    • Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      456591..457952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179308.1 → NP_012047.1  TPA: Rof1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLC6, P38867
      UniProtKB/TrEMBL
      C7GW82, C8Z9X3, N1P4V2
      Conserved Domains (1) summary
      COG5037
      Location:2 → 249
      TOS9; Gluconate transport-inducing protein [Signal transduction mechanisms / Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38867.2

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