HSP150 heat shock protein HSP150 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HSP150
Official Full Name: heat shock protein HSP150
Primary source: SGD:S000003695
Locus tag: YJL159W
See related: AllianceGenome:SGD:S000003695; FungiDB:YJL159W; VEuPathDB:YJL159W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CCW7; ORE1; PIR2
Summary: Enables ATP hydrolysis activity. A structural constituent of cell wall. Involved in fungal-type cell wall organization. Located in cellular bud scar and extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HSP150 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (120449..121690)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results from clinical isolates of S. cerevisiae found Hsp150 to be expressed at higher levels which presumably contribute to strain virulence and fungal pathogenicity.
Title: Characterization of Cell Wall Proteins in Saccharomyces cerevisiae Clinical Isolates Elucidates Hsp150p in Virulence.
Authentic Hsp150 from the yeast culture medium, as well as Hsp150 and the C-terminal fragment produced in Escherichia coli, exhibited ATPase activity nearly three times higher than the published activity of the chaperone Kar2p/BiP.
Title: ATPase activity of a yeast secretory glycoprotein allows ER exit during inactivation of COPII components Sec24p and Sec13p.
Sec14 function was required for the route followed by Bgl2, whereas trafficking of other secreted proteins, including Hsp150, Cts1, Scw4, Scw10, Exg1, Cis3, and Ygp1, still occurred, indicating Sec14 regulates specific trans-Golgi export pathways.
Title: Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways.
It is highly probable that the modified Ccw7 protein does not contribute to the increased hydrophobicity of film-forming strains but it may influence molecular reorganization of the cell wall during stress adaptation.
Title: Characterization of Ccw7p cell wall proteins and the encoding genes of Saccharomyces cerevisiae wine yeast strains: relevance for flor formation.
a soluble cargo protein, Hsp150, is selected actively and specifically to budding sites lacking normal Sec24p by a signature residing in its C-terminal domain
Title: Active and specific recruitment of a soluble cargo protein for endoplasmic reticulum exit in the absence of functional COPII component Sec24p.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of cell wall	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cell wall	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cell wall	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud scar	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in fungal-type cell wall	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type cell wall	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock protein HSP150

NP_012376.3

O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication