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    NUP192 Nup192p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853410, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NUP192
    Official Full Name
    Nup192p
    Primary source
    SGD:S000003576
    Locus tag
    YJL039C
    See related
    AllianceGenome:SGD:S000003576; FungiDB:YJL039C; VEuPathDB:YJL039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of nuclear pore. Involved in nuclear pore organization and regulation of nucleocytoplasmic transport. Located in nucleus. Part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NUP192 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (368748..373799, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mhp1p Neighboring gene FG-nucleoporin NSP1 Neighboring gene tRNA-Asp Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nup192p is a conserved nucleoporin with a preferential location at the inner site of the nuclear membrane. Kosova B, et al. J Biol Chem, 1999 Aug 6. PMID 10428845
    2. Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex. Sampathkumar P, et al. Structure, 2013 Apr 2. PMID 23499021, Free PMC Article
    3. Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors. Andersen KR, et al. Elife, 2013 Jun 11. PMID 23795296, Free PMC Article
    4. Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex. Li Z, et al. Cell Res, 2022 May. PMID 35301440, Free PMC Article
    5. Yeast nuclear pore complex assembly defects determined by nuclear envelope reconstruction. Gomez-Ospina N, et al. J Struct Biol, 2000 Oct. PMID 11121302

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both Nup188 and Nup192 specifically bind FG-repeats and are able to translocate through NPCs by facilitated diffusion
      Title: Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear pore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore inner ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore inner ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nup192p
    NP_012495.1
    • Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      368748..373799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181473.1 → NP_012495.1  TPA: Nup192p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012495.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWE4, P47054
      UniProtKB/TrEMBL
      A6ZPT7, G2WGX9, N1P0X2
      Conserved Domains (1) summary
      pfam11894
      Location:134 → 1677
      Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47054.1

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