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    SAG1 Sag1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAG1
    Official Full Name
    Sag1p
    Primary source
    SGD:S000003764
    Locus tag
    YJR004C
    See related
    AllianceGenome:SGD:S000003764; FungiDB:YJR004C; VEuPathDB:YJR004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AG(ALPHA)1
    Summary
    Enables cell adhesion molecule binding activity. Involved in agglutination involved in conjugation with cellular fusion. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAG1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (442909..444861, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene rRNA-processing protein MPP10 Neighboring gene Mrx12p Neighboring gene Apl1p Neighboring gene Lso1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Environmentally induced reversible conformational switching in the yeast cell adhesion protein alpha-agglutinin. Zhao H, et al. Protein Sci, 2001 Jun. PMID 11369849, Free PMC Article
    2. Alpha-agglutinin expression in Saccharomyces cerevisiae. Wojciechowicz D, et al. Biochem Biophys Res Commun, 1989 May 30. PMID 2659000
    3. An alpha-specific gene, SAG1 is required for sexual agglutination in Saccharomyces cerevisiae. Doi S, et al. Curr Genet, 1989 Jun. PMID 2673555
    4. Purification of the inducible alpha-agglutinin of S. cerevisiae and molecular cloning of the gene. Hauser K, et al. FEBS Lett, 1989 Sep 25. PMID 2676603
    5. AG alpha 1 is the structural gene for the Saccharomyces cerevisiae alpha-agglutinin, a cell surface glycoprotein involved in cell-cell interactions during mating. Lipke PN, et al. Mol Cell Biol, 1989 Aug. PMID 2677666, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in agglutination involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sag1p
    NP_012537.1
    • Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      442909..444861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181661.1 → NP_012537.1  TPA: Sag1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWH8, P20840
      UniProtKB/TrEMBL
      B3LQA2, D3UF71, N1P100
      Conserved Domains (1) summary
      smart01056
      Location:50 → 300
      Candida_ALS_N; Cell-wall agglutinin N-terminal ligand-sugar binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20840.2

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