TMA22 Tma22p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TMA22
Official Full Name: Tma22p
Primary source: SGD:S000003775
Locus tag: YJR014W
See related: AllianceGenome:SGD:S000003775; FungiDB:YJR014W; VEuPathDB:YJR014W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable RNA binding activity. Involved in ribosome disassembly. Acts upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Is active in cytoplasm. Used to study autism spectrum disorder. Orthologous to human DENR (density regulated re-initiation and release factor). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay.
Title: Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay.
40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.
Title: 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation reinitiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

NP_012548.1

Ribosome-associated protein; involved along with heterodimeric partner Tma20p in recycling of 40S ribosomal subunits; involved in nonsense-mediated mRNA decay (NMD); contains a putative RNA binding domain; localizes to the cytoplasm in HTP studies; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress