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    MNR2 putative Mg(2+) transporter MNR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MNR2
    Official Full Name
    putative Mg(2+) transporter MNR2
    Primary source
    SGD:S000001547
    Locus tag
    YKL064W
    See related
    AllianceGenome:SGD:S000001547; FungiDB:YKL064W; VEuPathDB:YKL064W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables magnesium ion transmembrane transporter activity. Involved in intracellular magnesium ion homeostasis. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MNR2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (317764..320673)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Dpc7p Neighboring gene Yet1p Neighboring gene uncharacterized protein Neighboring gene stress-responsive transcriptional activator MSN4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of microtubule dynamic instability by the carboxy-terminal tail of β-tubulin. Fees CP, et al. Life Sci Alliance, 2018 May. PMID 29963657, Free PMC Article
    2. Bovine pancreatic trypsin inhibitor is a new antifungal peptide that inhibits cellular magnesium uptake. Bleackley MR, et al. Mol Microbiol, 2014 Jun. PMID 24750237
    3. Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. MacDiarmid CW, et al. J Biol Chem, 1998 Jan 16. PMID 9430719
    4. Regulation of Alr1 Mg transporter activity by intracellular magnesium. Lim PH, et al. PLoS One, 2011. PMID 21738593, Free PMC Article
    5. MNR2 regulates intracellular magnesium storage in Saccharomyces cerevisiae. Pisat NP, et al. Genetics, 2009 Nov. PMID 19720860, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Mnr2 was localized to the vacuole membrane, implicating this organelle in Mg storage.
      Title: MNR2 regulates intracellular magnesium storage in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular magnesium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular magnesium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole-mitochondrion membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative Mg(2+) transporter MNR2
    NP_012859.1
    • Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      317764..320673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179630.1 → NP_012859.1  TPA: putative Mg(2+) transporter MNR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012859.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXM3, P35724
      UniProtKB/TrEMBL
      B3LR27, C8ZCA8, G2WHW8, N1P0L0
      Conserved Domains (1) summary
      cd12829
      Location:500 → 965
      Alr1p-like; Saccharomyces cerevisiae Alr1p-like subfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35724.1

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