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    LOT6 flavin-dependent quinone reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850698, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LOT6
    Official Full Name
    flavin-dependent quinone reductase
    Primary source
    SGD:S000004001
    Locus tag
    YLR011W
    See related
    AllianceGenome:SGD:S000004001; FungiDB:YLR011W; VEuPathDB:YLR011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables NAD(P)H dehydrogenase (quinone) activity. Involved in apoptotic process and cellular response to oxidative stress. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LOT6 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (169103..169678)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ten1p Neighboring gene tRNA-Ser Neighboring gene uncharacterized protein Neighboring gene Gat3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification. Sollner S, et al. FEBS J, 2007 Mar. PMID 17298444
    2. The Saccharomyces cerevisiae quinone oxidoreductase Lot6p: stability, inhibition and cooperativity. Megarity CF, et al. FEMS Yeast Res, 2014 Aug. PMID 24866129
    3. Epoxidation of conjugated C=C-bonds and sulfur-oxidation of thioethers mediated by NADH:FMN-dependent oxidoreductases. Mueller NJ, et al. Org Biomol Chem, 2009 Mar 21. PMID 19262930
    4. The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis. Sollner S, et al. FEMS Yeast Res, 2009 Sep. PMID 19709309
    5. Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae. Sollner S, et al. Biochemistry, 2009 Sep 15. PMID 19618916, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using hexahistidine tagged, recombinant Lot6p, the authors determined the steady-state enzyme kinetic parameters with both NADH and NADPH as electron donors; no cooperativity was observed with these substrates.
      Title: The Saccharomyces cerevisiae quinone oxidoreductase Lot6p: stability, inhibition and cooperativity.
    2. The authors propose that Lot6p is directly involved in the control of the apoptosis-like cell death in yeast.
      Title: The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis.
    3. Hydride transfer, and not an enzyme conformational change, is rate-determining in the Lot6 reductive half-reaction. In the oxidative half-reaction, reduced enzyme reacted in a single phase with six quinone substrates tested.
      Title: Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae.
    4. Lot6-proteasome complex can be regarded as a redox switch in which the quinone reductase acts as a sensor for oxidative stress
      Title: Quinone reductase acts as a redox switch of the 20S yeast proteasome.
    5. LOT6 is a FMN-dependent reductase with a potential role in quinone detoxification.
      Title: Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD(P)H dehydrogenase (quinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flavin-dependent quinone reductase
    NP_013111.1
    • FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      169103..169678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181898.1 → NP_013111.1  TPA: flavin-dependent quinone reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY13, Q07923
      UniProtKB/TrEMBL
      A7A0R6, B3LSY4, B5VMV3, C7GXF7, C8ZCY3, G2WIK5, N1P0D3
      Conserved Domains (1) summary
      COG0431
      Location:1 → 189
      SsuE; NAD(P)H-dependent FMN reductase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07923.1

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