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    RPL22A ribosomal 60S subunit protein L22A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL22A
    Official Full Name
    ribosomal 60S subunit protein L22A
    Primary source
    SGD:S000004051
    Locus tag
    YLR061W
    See related
    AllianceGenome:SGD:S000004051; FungiDB:YLR061W; VEuPathDB:YLR061W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of ribosome. Involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to several human genes including RPL22L1 (ribosomal protein L22 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL22A in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (263194..263948)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rex2p Neighboring gene phenylalanine--tRNA ligase subunit beta Neighboring gene 25S rRNA (uracil2843-N3)-methyltransferase Neighboring gene Per33p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rpl22 is required for IME1 mRNA translation and meiotic induction in S. cerevisiae. Kim SJ, et al. Cell Div, 2016. PMID 27478489, Free PMC Article
    2. CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Beaupere C, et al. Cell Rep, 2017 Feb 21. PMID 28228255, Free PMC Article
    3. Introns provide a platform for intergenic regulatory feedback of RPL22 paralogs in yeast. Abrhámová K, et al. PLoS One, 2018. PMID 29304067, Free PMC Article
    4. Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Chan CT, et al. Nat Commun, 2012 Jul 3. PMID 22760636, Free PMC Article
    5. Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity. Maitra N, et al. Elife, 2020 May 20. PMID 32432546, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L22A
    NP_013162.1
    • Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      263194..263948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181948.1 → NP_013162.1  TPA: ribosomal 60S subunit protein L22A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY63, P05749
      UniProtKB/TrEMBL
      A7A0W7, B3LT32, C8ZD33, G2WIQ4, N1P103
      Conserved Domains (1) summary
      pfam01776
      Location:15 → 110
      Ribosomal_L22e; Ribosomal L22e protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05749.3

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