CHS5 Chs5p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CHS5
Official Full Name: Chs5p
Primary source: SGD:S000004322
Locus tag: YLR330W
See related: AllianceGenome:SGD:S000004322; FungiDB:YLR330W; VEuPathDB:YLR330W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CAL3
Summary: Enables small GTPase binding activity. Involved in several processes, including Golgi to plasma membrane transport; ascospore wall assembly; and chitin catabolic process. Located in cytoplasm. Part of exomer complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CHS5 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (787664..789679)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chs5p is essential for structural integrity of the Chs5/6 complex and may act as a scaffold through which the other subunits assemble. Our results suggest a model of protein sorting at the TGN.
Title: Chs5/6 complex: a multiprotein complex that interacts with and conveys chitin synthase III from the trans-Golgi network to the cell surface.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ascospore wall assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular bud site selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conjugation with cellular fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
part_of exomer complex	IBA Inferred from Biological aspect of Ancestor more info
part_of exomer complex	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Chs5p

NP_013434.1

Component of the exomer complex; the exomer which also contains Csh6p, Bch1p, Bch2p, and Bud7, is involved in the export of select proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

787664..789679

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182219.1 → NP_013434.1 TPA: Chs5p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013434.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYX2, Q12114

UniProtKB/TrEMBL

G2WJF1

Conserved Domains (4) summary

COG5271
Location:366 → 607

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd13945
Location:4 → 76

Chs5_N; N-terminal dimerization domain of Chs5 and similar proteins

cd17742
Location:172 → 255

BRCT_CHS5_like; BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins

pfam16893
Location:77 → 165

fn3_2; Fibronectin type III domain