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    MDM1 Mdm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MDM1
    Official Full Name
    Mdm1p
    Primary source
    SGD:S000004572
    Locus tag
    YML104C
    See related
    AllianceGenome:SGD:S000004572; FungiDB:YML104C; VEuPathDB:YML104C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity. Involved in mitochondrion inheritance; piecemeal microautophagy of the nucleus; and vacuole-ER tethering. Located in cell periphery and fungal-type vacuole. Is active in nucleus-vacuole junction. Used to study autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX13 (sorting nexin 13) and SNX25 (sorting nexin 25). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MDM1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (58939..62322, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene orotate phosphoribosyltransferase URA5 Neighboring gene RNA-binding signal recognition particle subunit SEC65 Neighboring gene Nup188p Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein. McConnell SJ, et al. J Cell Biol, 1992 Jul. PMID 1378448, Free PMC Article
    2. Intermediate filament formation by a yeast protein essential for organelle inheritance. McConnell SJ, et al. Science, 1993 Apr 30. PMID 8480179
    3. Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance. Fisk HA, et al. J Cell Biol, 1997 Aug 11. PMID 9245780, Free PMC Article
    4. Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein. Henne WM, et al. J Cell Biol, 2015 Aug 17. PMID 26283797, Free PMC Article
    5. Temperature-sensitive yeast mutants defective in mitochondrial inheritance. McConnell SJ, et al. J Cell Biol, 1990 Sep. PMID 2202739, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation.
      Title: Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation.
    2. Mdm1 coordinates fatty acid activation adjacent to the vacuole to promote lipid droplet production in response to stress, thus maintaining endoplasmic reticulum homeostasis.
      Title: Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis.
    3. Mdm1 is endoplasmic reticulum anchored and contacts the vacuole surface in trans via its lipid-binding PX domain.
      Title: Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole-ER tethering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus-vacuole junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus-vacuole junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mdm1p
    NP_013603.1
    • PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      58939..62322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182466.1 → NP_013603.1  TPA: Mdm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013603.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0I0, Q01846, Q04196
      UniProtKB/TrEMBL
      G2WJV2
      Conserved Domains (4) summary
      cd06876
      Location:763 → 900
      PX_MDM1p; The phosphoinositide binding Phox Homology domain of yeast MDM1p
      smart00313
      Location:85 → 276
      PXA; Domain associated with PX domains
      pfam08628
      Location:993 → 1106
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:462 → 567
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01846.3

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