TSL1 trehalose 6-phosphate synthase/phosphatase complex subunit [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TSL1
Official Full Name: trehalose 6-phosphate synthase/phosphatase complex subunit
Primary source: SGD:S000004566
Locus tag: YML100W
See related: AllianceGenome:SGD:S000004566; FungiDB:YML100W; VEuPathDB:YML100W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme regulator activity. Contributes to alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity and trehalose-phosphatase activity. Involved in trehalose biosynthetic process. Located in cytoplasm. Part of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to trehalose-phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to trehalose-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in trehalose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trehalose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose metabolism in response to stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	IBA Inferred from Biological aspect of Ancestor more info
part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NP_013608.1

Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication

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