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    USA1 Usa1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    USA1
    Official Full Name
    Usa1p
    Primary source
    SGD:S000004491
    Locus tag
    YML029W
    See related
    AllianceGenome:SGD:S000004491; FungiDB:YML029W; VEuPathDB:YML029W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables molecular adaptor activity. Involved in ERAD pathway; mRNA splicing, via spliceosome; and positive regulation of protein autoubiquitination. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See USA1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (217362..219878)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ndc1p Neighboring gene Rcf1p Neighboring gene thioredoxin peroxidase TSA1 Neighboring gene Yox1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. Benitez EM, et al. FEBS Lett, 2011 Oct 3. PMID 21871892
    2. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. Carroll SM, et al. J Biol Chem, 2010 Feb 19. PMID 19940128, Free PMC Article
    3. Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function. Peterson BG, et al. bioRxiv, 2023 Apr 3. PMID 37066402, Free PMC Article
    4. N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Zattas D, et al. Mol Biol Cell, 2013 Apr. PMID 23363603, Free PMC Article
    5. Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1. Peterson BG, et al. Elife, 2019 Nov 12. PMID 31713515, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Usa1 has two important roles in ERAD substrate ubiquitylation
      Title: Usa1 protein facilitates substrate ubiquitylation through two separate domains.
    2. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.
      Title: Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ERAD pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Usa1p
    NP_013683.1
    • Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      217362..219878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182387.1 → NP_013683.1  TPA: Usa1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013683.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZE5, Q03714
      UniProtKB/TrEMBL
      B3LLM3, B5VP97, C8ZEH5
      Conserved Domains (1) summary
      cl28922
      Location:276 → 341
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03714.1

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