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    SLZ1 Slz1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLZ1
    Official Full Name
    Slz1p
    Primary source
    SGD:S000005140
    Locus tag
    YNL196C
    See related
    AllianceGenome:SGD:S000005140; FungiDB:YNL196C; VEuPathDB:YNL196C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in meiotic cell cycle and negative regulation of pseudohyphal growth. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLZ1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (270275..271171, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Gcr2p Neighboring gene mRNA-binding protein WHI3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA methylation by the MIS complex regulates a cell fate decision in yeast. Agarwala SD, et al. PLoS Genet, 2012. PMID 22685417, Free PMC Article
    2. Systematic analysis of sporulation phenotypes in 624 non-lethal homozygous deletion strains of Saccharomyces cerevisiae. Briza P, et al. Yeast, 2002 Mar 30. PMID 11921089
    3. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Schwartz S, et al. Cell, 2013 Dec 5. PMID 24269006, Free PMC Article
    4. The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles. Ensinck I, et al. Elife, 2023 Jul 25. PMID 37490041, Free PMC Article
    5. Kar4, the yeast homolog of METTL14, is required for mRNA m6A methylation and meiosis. Park ZM, et al. PLoS Genet, 2023 Aug. PMID 37603553, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Slz1p
    NP_014203.1
    • Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during the induction of sporulation; homologous to human ZCH13H3, a subunit of the mammalian m6A methyltransferase complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      270275..271171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183034.1 → NP_014203.1  TPA: Slz1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Z1, P40167
      UniProtKB/TrEMBL
      A6ZRP1, B3LP44, N1NWF3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40167.1

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