CRZ1 DNA-binding transcription factor CRZ1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CRZ1
Official Full Name: DNA-binding transcription factor CRZ1
Primary source: SGD:S000004972
Locus tag: YNL027W
See related: AllianceGenome:SGD:S000004972; FungiDB:YNL027W; VEuPathDB:YNL027W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HAL8; TCN1
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular hyperosmotic salinity response; cellular response to alkaline pH; and chitin biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; patent ductus arteriosus; and piebaldism. Orthologous to several human genes including PRDM14 (PR/SET domain 14); PRDM6 (PR/SET domain 6); and SCRT1 (scratch family transcriptional repressor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CRZ1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (579580..581616)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of enhanced salt tolerance in Saccharomyces cerevisiae by CRZ1 overexpression.
Title: Mechanism of enhanced salt tolerance in Saccharomyces cerevisiae by CRZ1 overexpression.
Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics.
Title: Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics.
Study defines at the genomic-wide level the kinetics of binding of Crz1 to gene promoters in response to alkaline stress, confirms diverse previously known Crz1 targets and identifies many putative novel ones.
Title: Genome-wide recruitment profiling of transcription factor Crz1 in response to high pH stress.
Experimental data and mathematical models substantiate the existence of two stress-responsive Crz1-binding sites in the ENA1 promoter and estimate that the contribution of Crz1 to the early response of the ENA1 promoter is about 60%.
Title: Regulation of the Na+/K+-ATPase Ena1 Expression by Calcineurin/Crz1 under High pH Stress: A Quantitative Study.
CRZ1 mediates transcriptional regulation of a large number of genes of diverse pathways including a negative feedback regulation of the calcium homeostasis system. (Review)
Title: The CRaZy Calcium Cycle.
Ypk1 and Plb1 interact to alter sphingolipid metabolism up-regulates PLB1 expression via Crz1
Title: Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.
These data establish that activation of Ca(2+) signalling pathways and the downstream activation of the Crz1 transcription factor contribute to arsenic tolerance in the eukaryotic model organism Saccharomyces cerevisiae.
Title: Arsenic stress elicits cytosolic Ca(2+) bursts and Crz1 activation in Saccharomyces cerevisiae.
Crz1 destabilizes Msn2/Msn4 in the nuclei of cells in response to Ca2+ signalling.
Title: Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca(2+) in Saccharomyces cerevisiae.
ethanol activates the calcineurin/Crz1 pathway and CRZ1 is crucial for cell survival under ethanol-induced stress
Title: Ethanol stress stimulates the Ca2+-mediated calcineurin/Crz1 pathway in Saccharomyces cerevisiae.
Crz1 exhibits short bursts of nuclear localization (typically lasting 2 min) that occur stochastically in individual cells and propagate to the expression of downstream genes
Title: Frequency-modulated nuclear localization bursts coordinate gene regulation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	HDA more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular hyperosmotic salinity response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to alkaline pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to blue light	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular potassium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular potassium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-binding transcription factor CRZ1

NP_014371.1

Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

579580..581616

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182866.1 → NP_014371.1 TPA: DNA-binding transcription factor CRZ1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014371.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1F1, P53968

UniProtKB/TrEMBL

A6ZS54, G2WL35, N1NXM7

Conserved Domains (2) summary

COG5048
Location:139 → 617

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:571 → 591

ZF_C2H2; C2H2 Zn finger [structural motif]