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    SLD7 Sld7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLD7
    Official Full Name
    Sld7p
    Primary source
    SGD:S000005586
    Locus tag
    YOR060C
    See related
    AllianceGenome:SGD:S000005586; FungiDB:YOR060C; VEuPathDB:YOR060C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-11
    Summary
    Involved in regulation of DNA-templated DNA replication initiation. Located in chromosome, centromeric region. Part of DNA replication preinitiation complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLD7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (440390..441163, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene putative hydrolase Neighboring gene casein kinase 2 catalytic subunit CKA2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiomics Approach to Novel Therapeutic Targets for Cancer and Aging-Related Diseases: Role of Sld7 in Yeast Aging Network. Dayan IE, et al. OMICS, 2017 Feb. PMID 28118095
    2. A low cost PS based microfluidic platform to investigate cell cycle towards developing a therapeutic strategy for cancer. Odabasi IE, et al. Biomed Microdevices, 2018 Jul 5. PMID 29974243
    3. Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Altmann K, et al. Mol Biol Cell, 2005 Nov. PMID 16135527, Free PMC Article
    4. The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3. Itou H, et al. Acta Crystallogr D Biol Crystallogr, 2015 Aug. PMID 26249346
    5. Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing. Tanaka S, et al. Curr Biol, 2011 Dec 20. PMID 22169533

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the crystal structure of Sld7 in complex with Sld3 is presented. Sld7 comprises two structural domains.
      Title: The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in nuclear envelope HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sld7p
    NP_014703.1
    • Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria; ortholog of human MTBP, which is a DNA replication origin firing factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      440390..441163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183479.1 → NP_014703.1  TPA: Sld7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014703.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2C3, O00023, Q08457
      UniProtKB/TrEMBL
      G2WMT8, N1NYA6
      Conserved Domains (2) summary
      pfam18596
      Location:181 → 255
      Sld7_C; Sld7 C-terminal domain
      pfam18636
      Location:3 → 125
      Sld7_N; Mitochondrial morphogenesis protein SLD7 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08457.1

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