Thy1 Thy-1 cell surface antigen [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thy1provided by RGD
Official Full Name: Thy-1 cell surface antigenprovided by RGD
Primary source: RGD:3860
See related: EnsemblRapid:ENSRNOG00000006604 AllianceGenome:RGD:3860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD7
Summary: Enables GPI anchor binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including T cell receptor signaling pathway; focal adhesion assembly; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within with a positive effect on cell-cell signaling and negative regulation of neuron projection regeneration. Located in several cellular components, including growth cone; neuron projection membrane; and neuronal cell body membrane. Biomarker of retinal disease and retinal ischemia. Orthologous to human THY1 (Thy-1 cell surface antigen). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 2242.5) and Brain (RPKM 1279.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53286396..53291541)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (44389495..44394688)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48382121..48387271)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
Title: Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
Therapeutic benefits of CD90-negative cardiac stromal cells in rats with a 30-day chronic infarct has been demonstrated.
Title: Therapeutic benefits of CD90-negative cardiac stromal cells in rats with a 30-day chronic infarct.
Intracellular Ca2+ signals and Cx43 hemichannel opening participate as key steps in the regulation of Thy-1-induced astrocyte migration.
Title: Intracellular Ca(2+) Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration.
THY1 is expressed in the anterior lobe of the rat pituitary gland.THY1 is a novel specific marker of thyrotropes, which produce TSH.
Title: Identification of THY1 as a novel thyrotrope marker and THY1 antibody-mediated thyrotrope isolation in the rat anterior pituitary gland.
Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model
Title: Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model.
Thymocyte antigen 1 (Thy-1) is a highly expressed cell-surface protein in lung fibroblasts, which plays a key role in fetal alveolarization by coordinating the differentiation and lipid homeostasis of alveolar lipid containing fibroblasts.
Title: Disruption of THY-1 signaling in alveolar lipofibroblasts in experimentally induced congenital diaphragmatic hernia.
first report that Thy1 colocalizes and coimmunoprecipitates with a membrane-spanning protein in retina, that Thy1 complexes with an ion channel protein in any tissue, and that a GPI-anchored protein associates with an HCN channel subunit protein.
Title: Thy1 associates with the cation channel subunit HCN4 in adult rat retina.
Study is the first to demonstrate a functional link between alphavbeta3 integrin and P2X7 receptors, and to reveal an important, hitherto unanticipated, role for P2X7 in calcium-dependent signaling required for Thy-1-stimulated astrocyte adhesion.
Title: ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation.
Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts.
Title: Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts.
The Thy1-GFP rat is a novel transgenic tool that enables direct visualization of facial nerve regeneration after injury.
Title: A new model for facial nerve research: the novel transgenic Thy1-GFP rat.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94841 (e-PCR)
- UniSTS:120087

PMC22863P1 (e-PCR)
- UniSTS:272165

D8Wox34 (e-PCR)
- UniSTS:519012

D8Arb8 (e-PCR), detects polymorphism
- UniSTS:228205

BE096371 (e-PCR)
- UniSTS:260547

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GPI anchor binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mast cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast proliferation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within_positive_effect negative regulation of neuron projection regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cellular extravasation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Rho-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinal cone cell development	ISO Inferred from Sequence Orthology more info
involved_in retinal cone cell development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thy-1 membrane glycoprotein

Names: CD90; Thy-1 protein; Thymus cell surface antigen; thy-1 antigen; thy-1 glycoprotein; thymus cell antigen 1, theta

NP_036805.1

EC 3.1.26.4

XP_017450965.1

EC 3.1.26.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012673.2 → NP_036805.1 thy-1 membrane glycoprotein preproprotein

Status: VALIDATED

Source sequence(s)

CB741211, CB797376, CO561977, X03150

UniProtKB/Swiss-Prot

P01830

UniProtKB/TrEMBL

A0A8I5ZPP2, A6J3U9, A6J3V0

Related

ENSRNOP00000079974.2, ENSRNOT00000095277.2

Conserved Domains (2) summary

cd00096
Location:33 → 40

Ig; Ig strand B [structural motif]

cl11960
Location:24 → 122

Ig; Immunoglobulin domain