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    Gmeb2 glucocorticoid modulatory element binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmeb2provided by RGD
    Official Full Name
    glucocorticoid modulatory element binding protein 2provided by RGD
    Primary source
    RGD:620481
    See related
    EnsemblRapid:ENSRNOG00000013339 AllianceGenome:RGD:620481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human GMEB2 (glucocorticoid modulatory element binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 62.5), Spleen (RPKM 56.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmeb2 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188740210..188778377, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168362650..168400788, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176756006..176791960, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 11 Neighboring gene helicase with zinc finger 2 Neighboring gene uncharacterized LOC120101833 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene stathmin 3 Neighboring gene ARF related protein 1 Neighboring gene zinc finger CCCH-type and G-patch domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex. Chen J, et al. Biochemistry, 2004 Jan 13. PMID 14705952
    2. Cloning and characterization of a novel binding factor (GMEB-2) of the glucocorticoid modulatory element. Zeng H, et al. J Biol Chem, 1998 Jul 10. PMID 9651376
    3. Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins. Zeng H, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734202, Free PMC Article
    4. The factor binding to the glucocorticoid modulatory element of the tyrosine aminotransferase gene is a novel and ubiquitous heteromeric complex. Oshima H, et al. J Biol Chem, 1995 Sep 15. PMID 7665613
    5. Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. Kaul S, et al. Mol Endocrinol, 2000 Jul. PMID 10894151

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IC
    Inferred by Curator
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucocorticoid modulatory element-binding protein 2
    Names
    GMEB-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389211.1 → NP_001376140.1  glucocorticoid modulatory element-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM28
      Related
      ENSRNOP00000085762.2, ENSRNOT00000101387.2
      Conserved Domains (1) summary
      cl02536
      Location:7 → 51
      SAND; SAND domain

    2. NM_031803.2 → NP_113991.2  glucocorticoid modulatory element-binding protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88873, Q9JL86, Q9JL87, Q9JL88, Q9QUZ7
      UniProtKB/TrEMBL
      A6KM27, G3V7R3
      Related
      ENSRNOP00000049928.6, ENSRNOT00000044026.7
      Conserved Domains (1) summary
      smart00258
      Location:90 → 163
      SAND; SAND domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188740210..188778377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284662.1 → XP_063140732.1  glucocorticoid modulatory element-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O88873, Q9JL86, Q9JL87, Q9JL88, Q9QUZ7

    2. XM_063284663.1 → XP_063140733.1  glucocorticoid modulatory element-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A6KM28
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88873.1 GenPept UniProtKB/Swiss-Prot:O88873

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