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    Eif2s3 eukaryotic translation initiation factor 2 subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299027, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif2s3provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 2 subunit gammaprovided by RGD
    Primary source
    RGD:1561279
    See related
    EnsemblRapid:ENSRNOG00000060793 AllianceGenome:RGD:1561279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PP42; Eif2g; Eif2s3x
    Summary
    Predicted to enable methionyl-initiator methionine tRNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Predicted to be active in synapse. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 486.7), Spleen (RPKM 468.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif2s3 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (62910292..62933936, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (58916513..58939923, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63268106..63291125, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein X-linked Neighboring gene uncharacterized LOC134484053 Neighboring gene uncharacterized LOC134484164 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat liver pp49, a protein that forms complexes with protein kinase CK2, is composed of the beta and the gamma subunits of translation initiation factor eIF-2. Gil C, et al. Biochem Biophys Res Commun, 1996 Aug 23. PMID 8780732
    2. Shape and location of eukaryotic initiation factor eIF-2 on the 40S ribosomal subunit of rat liver. Immunoelectron-microscopic and hydrodynamic investigations. Bommer UA, et al. Eur J Biochem, 1988 Mar 15. PMID 2450747
    3. Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. Kruger M, et al. Proc Natl Acad Sci U S A, 2000 Jul 18. PMID 10900014, Free PMC Article
    4. eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. Borck G, et al. Mol Cell, 2012 Nov 30. PMID 23063529, Free PMC Article
    5. Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. Young-Baird SK, et al. Mol Cell, 2020 Feb 20. PMID 31836389, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionyl-initiator methionine tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 3, X-linked
    Names
    eIF-2-gamma X
    eIF2-gamma
    eIF2-gamma X
    eukaryotic translation initiation factor 2 subunit gamma, X-linked
    eukaryotic translation initiation factor 2, subunit 3 gamma
    eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
    NP_001094012.1
    XP_063135947.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100542.1 → NP_001094012.1  eukaryotic translation initiation factor 2 subunit 3, X-linked

      See identical proteins and their annotated locations for NP_001094012.1

      Status: VALIDATED

      Source sequence(s)
      AI029347, BC091286, BC166783, BM392036, EV772689
      UniProtKB/Swiss-Prot
      B0BN96, B2RYH8, P81795, Q5BJX8
      UniProtKB/TrEMBL
      A0A8L2R4R9
      Related
      ENSRNOP00000070817.3, ENSRNOT00000092019.3
      Conserved Domains (1) summary
      PTZ00327
      Location:13 → 466
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      62910292..62933936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279877.1 → XP_063135947.1  eukaryotic translation initiation factor 2 subunit 3, X-linked isoform X1

      UniProtKB/Swiss-Prot
      B0BN96, B2RYH8, P81795, Q5BJX8
      UniProtKB/TrEMBL
      A0A8L2R4R9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81795.2 GenPept UniProtKB/Swiss-Prot:P81795

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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