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    Cox6b1 cytochrome c oxidase subunit 6B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cox6b1provided by RGD
    Official Full Name
    cytochrome c oxidase subunit 6B1provided by RGD
    Primary source
    RGD:1584097
    See related
    EnsemblRapid:ENSRNOG00000024309 AllianceGenome:RGD:1584097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cox6b
    Summary
    Predicted to be involved in substantia nigra development. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to human COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 5203.7), Muscle (RPKM 3130.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox6b1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95002513..95011516, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85875080..85884081, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89075987..89084834, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene uroplakin 1A Neighboring gene ETS variant transcription factor 2 Neighboring gene RNA binding motif protein 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of COX6B1 protects against I/R‑induced neuronal injury in rat hippocampal neurons. Yang S, et al. Mol Med Rep, 2019 Jun. PMID 31059068, Free PMC Article
    2. COX6B1 relieves hypoxia/reoxygenation injury of neonatal rat cardiomyocytes by regulating mitochondrial function. Zhang W, et al. Biotechnol Lett, 2019 Jan. PMID 30311029, Free PMC Article
    3. Structure of the intact 14-subunit human cytochrome c oxidase. Zong S, et al. Cell Res, 2018 Oct. PMID 30030519, Free PMC Article
    4. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Chen S, et al. Neurochem Res, 2012 Dec. PMID 22926577
    5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 6B1
    Names
    COX VIb-1
    cytochrome c oxidase subunit VIb
    cytochrome c oxidase, subunit VIb polypeptide 1
    NP_001138745.1
    XP_006228857.1
    XP_038947145.1
    XP_063130482.1
    XP_063130488.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145273.1 → NP_001138745.1  cytochrome c oxidase subunit 6B1

      See identical proteins and their annotated locations for NP_001138745.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A8X0, A6JA04
      Conserved Domains (1) summary
      cd00926
      Location:8 → 85
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95002513..95011516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228795.3 → XP_006228857.1  cytochrome c oxidase subunit 6B1 isoform X1

      See identical proteins and their annotated locations for XP_006228857.1

      UniProtKB/TrEMBL
      A0A8I6A8X0, A6JA04
      Conserved Domains (1) summary
      cd00926
      Location:8 → 85
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. XM_039091217.2 → XP_038947145.1  cytochrome c oxidase subunit 6B1 isoform X2

      UniProtKB/TrEMBL
      A6JA04, D3ZSB0
      Related
      ENSRNOP00000030997.3, ENSRNOT00000032026.5
      Conserved Domains (1) summary
      cd00926
      Location:8 → 70
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    3. XM_063274412.1 → XP_063130482.1  cytochrome c oxidase subunit 6B1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8X0, A6JA04

    4. XM_063274418.1 → XP_063130488.1  cytochrome c oxidase subunit 6B1 isoform X2

      UniProtKB/TrEMBL
      A6JA04, D3ZSB0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80430.1 GenPept UniProtKB/Swiss-Prot:P80430

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