U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Fgf5 fibroblast growth factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 14176, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fgf5provided by MGI
    Official Full Name
    fibroblast growth factor 5provided by MGI
    Primary source
    MGI:MGI:95519
    See related
    Ensembl:ENSMUSG00000029337 AllianceGenome:MGI:95519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    go; Fgf-5; Fgf3a; HBGF-5; angora
    Summary
    This gene encodes a secreted protein that is a member of a family of heparin-binding growth factors. The encoded protein regulates cell proliferation, particularly the growth of hair follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fgf5 in Genome Data Viewer
    Location:
    5 E3; 5 47.77 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (98402108..98424892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (98254184..98277033)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730035I17 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene PR domain containing 8 Neighboring gene STARR-seq mESC enhancer starr_13701 Neighboring gene cilia and flagella associated protein 299 Neighboring gene predicted gene, 34475 Neighboring gene microRNA 703

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 5
    Names
    fibroblast growth factor 3a
    heparin-binding growth factor 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277268.2NP_001264197.1  fibroblast growth factor 5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001264197.1

      Status: VALIDATED

      Source sequence(s)
      AC125073
      Consensus CDS
      CCDS80344.1
      UniProtKB/Swiss-Prot
      P15656
      Related
      ENSMUSP00000142420.2, ENSMUST00000200059.2
      Conserved Domains (1) summary
      cl00060
      Location:85114
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    2. NM_010203.6NP_034333.1  fibroblast growth factor 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034333.1

      Status: VALIDATED

      Source sequence(s)
      AC125073
      Consensus CDS
      CCDS19455.1
      UniProtKB/Swiss-Prot
      O88825, P15656
      UniProtKB/TrEMBL
      A0A7U3L698
      Related
      ENSMUSP00000031280.2, ENSMUST00000031280.2
      Conserved Domains (1) summary
      pfam00167
      Location:85214
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      98402108..98424892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)