Cabin1 calcineurin binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cabin1provided by MGI
Official Full Name: calcineurin binding protein 1provided by MGI
Primary source: MGI:MGI:1298375
See related: Ensembl:ENSMUSG00000020196 AllianceGenome:MGI:1298375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cain; Ppp3in; A330070M20Rik
Summary: Predicted to enable protein domain specific binding activity; protein phosphatase 2B binding activity; and protein phosphatase inhibitor activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to act upstream of or within signal transduction. Predicted to be located in aggresome; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in heart. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CABIN1 (calcineurin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 14.2), ovary adult (RPKM 14.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.56 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75481944..75600194, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75646110..75764357, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

calcineurin B1 plays a key role in seizure-induced dendrite growth suppression and may contribute to the neurobehavioral comorbidities of childhood epilepsy
Title: The Impact of Electrographic Seizures on Developing Hippocampal Dendrites Is Calcineurin Dependent.
Cabin1 inhibits p53 function on chromatin in the quiescent state; the presence of inactive p53 on some promoters might allow a prompt response upon DNA damage.
Title: Cabin1 restrains p53 activity on chromatin.
Calpain-dependent cleavage activates calcineurin to mediate calcium-triggered cell death.
Title: Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Jhu70 (e-PCR), detects polymorphism
- UniSTS:158724

NoName (e-PCR)
- UniSTS:236393

Cabin1 (e-PCR), detects polymorphism
- UniSTS:499076

D10Mit186 (e-PCR), detects polymorphism
- UniSTS:126086

MHAa38d3.seq (e-PCR)
- UniSTS:125169

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: calcineurin-binding protein cabin-1

Names: calcineurin inhibitor; protein phosphatase 3 inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172549.3 → NP_766137.2 calcineurin-binding protein cabin-1

See identical proteins and their annotated locations for NP_766137.2

Status: VALIDATED

Source sequence(s)

AK039606, BC051668, BC057551, BQ714836, BU705499, CN722898, CV884170

Consensus CDS

CCDS35938.1

UniProtKB/TrEMBL

B9EKC5, G3X8Q1

Related

ENSMUSP00000001712.7, ENSMUST00000001712.8

Conserved Domains (4) summary

PHA03247
Location:1915 → 2161

PHA03247; large tegument protein UL36; Provisional

COG0457
Location:34 → 210

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:90 → 118

TPR; TPR repeat [structural motif]

pfam09047
Location:2123 → 2157

MEF2_binding; MEF2 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

75481944..75600194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513020.5 → XP_006513083.1 calcineurin-binding protein cabin-1 isoform X2

UniProtKB/TrEMBL

B9EKC5

Conserved Domains (4) summary

PHA03247
Location:1886 → 2132

PHA03247; large tegument protein UL36; Provisional

COG0457
Location:34 → 210

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:90 → 118

TPR; TPR repeat [structural motif]

pfam09047
Location:2094 → 2128

MEF2_binding; MEF2 binding
XM_006513019.5 → XP_006513082.1 calcineurin-binding protein cabin-1 isoform X1

See identical proteins and their annotated locations for XP_006513082.1

UniProtKB/TrEMBL

B9EKC5, G3X8Q1

Conserved Domains (4) summary

PHA03247
Location:1915 → 2161

PHA03247; large tegument protein UL36; Provisional

COG0457
Location:34 → 210

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:90 → 118

TPR; TPR repeat [structural motif]

pfam09047
Location:2123 → 2157

MEF2_binding; MEF2 binding
XM_006513021.3 → XP_006513084.1 calcineurin-binding protein cabin-1 isoform X3

Conserved Domains (3) summary

sd00006
Location:191 → 218

TPR; TPR repeat [structural motif]

pfam09047
Location:1258 → 1292

MEF2_binding; MEF2 binding

pfam15058
Location:1111 → 1258

Speriolin_N; Speriolin N-terminus
XM_006513022.3 → XP_006513085.1 calcineurin-binding protein cabin-1 isoform X4

Conserved Domains (2) summary

pfam09047
Location:1045 → 1079

MEF2_binding; MEF2 binding

pfam15058
Location:898 → 1045

Speriolin_N; Speriolin N-terminus