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    alg2 ALG2 alpha-1,3/1,6-mannosyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 403068, updated on 4-Jan-2025

    Summary

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    Official Symbol
    alg2provided by ZNC
    Official Full Name
    ALG2 alpha-1,3/1,6-mannosyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060502-2
    See related
    AllianceGenome:ZFIN:ZDB-GENE-060502-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7145131
    Summary
    Predicted to enable alpha-1,3-mannosyltransferase activity and glycolipid mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See alg2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (27215938..27224074, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (27281315..27289502, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 245 Neighboring gene ferric chelate reductase 1 like Neighboring gene SEC61 translocon subunit beta Neighboring gene nuclear receptor subfamily 4, group A, member 3 Neighboring gene syntaxin 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. Montaville P, et al. Biochim Biophys Acta, 2006 Nov. PMID 17045351
    2. The N-glycome regulates the endothelial-to-hematopoietic transition. Kasper DM, et al. Science, 2020 Dec 4. PMID 33273096, Free PMC Article
    3. trappc11 is required for protein glycosylation in zebrafish and humans. DeRossi C, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912795, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • FLJ14511

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,3-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycolipid mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3/1,6-mannosyltransferase ALG2
    Names
    asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)
    asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)
    NP_001098406.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104936.2 → NP_001098406.2  alpha-1,3/1,6-mannosyltransferase ALG2

      Status: VALIDATED

      Source sequence(s)
      CU914485
      UniProtKB/TrEMBL
      A0A8M1NFU6, A0A8M6YTF8, F1QPS1
      Conserved Domains (2) summary
      cd03805
      Location:2 → 393
      GT1_ALG2_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2) ...
      COG0438
      Location:1 → 402
      RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      27215938..27224074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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