Sprr2a1 small proline-rich protein 2A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sprr2a1provided by MGI
Official Full Name: small proline-rich protein 2A1provided by MGI
Primary source: MGI:MGI:1330350
See related: Ensembl:ENSMUSG00000078664 AllianceGenome:MGI:1330350
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sprr2a; Sprr2a3
Summary: Predicted to enable lipid binding activity. Involved in antibacterial humoral response; defense response to Gram-positive bacterium; and host-mediated regulation of intestinal microbiota composition. Acts upstream of or within response to estradiol. Located in cytoplasm and nucleus. Is active in extracellular region and secretory granule. Is expressed in central nervous system; foregut; ovary; retina; and skin. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 5151.3), small intestine adult (RPKM 3157.6) and 4 other tissues See more
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (92123142..92129798)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92215835..92222491)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sprr2a is selectively expressed in the upper layer of the epithelium surrounding taste buds in the circumvallate papilla
Title: The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the circumvallate papilla.
Immunohistochemical staining revealed that Sprr2a protein is detected only in the adult uterus, and not in the ovary, oviduct or testis.
Title: Immunolocalisation and oestrogen regulation of small proline-rich protein 2a protein in the mouse uterus.
In non-lesional HPV8-CER transgenic skin StefinA and Sprr2 are indirect/direct transcriptional targets of HPV8
Title: Enhanced StefinA and Sprr2 expression during papilloma formation in HPV8 transgenic mice.
Small proline-rich proteins (SPRR2A) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.
Title: Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.
Data show that SPRR2a and b are allergen- and IL-13-induced in experimental allergic responses that may be involved in disease pathophysiology.
Title: Expression and regulation of small proline-rich protein 2 in allergic inflammation.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in host-mediated regulation of intestinal microbiota composition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cornified envelope	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small proline-rich protein 2A1

Names: small proline-rich protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.