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    Pnliprp1 pancreatic lipase related protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 18946, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pnliprp1provided by MGI
    Official Full Name
    pancreatic lipase related protein 1provided by MGI
    Primary source
    MGI:MGI:97723
    See related
    Ensembl:ENSMUSG00000042179 AllianceGenome:MGI:97723
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plrp1
    Summary
    Predicted to enable calcium ion binding activity and lipase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Orthologous to human PNLIPRP1 (pancreatic lipase related protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 301.3), spleen adult (RPKM 164.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Pnliprp1 in Genome Data Viewer
    Location:
    19 D2; 19 54.49 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (58717319..58732601)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (58728887..58744169)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810035K13 gene Neighboring gene RIKEN cDNA 1810018F18 gene Neighboring gene STARR-seq mESC enhancer starr_46584 Neighboring gene pancreatic lipase-related protein 2 Neighboring gene predicted gene, 52394

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipoprotein lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables triacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in high-density lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inactive pancreatic lipase-related protein 1
    Names
    PL-RP1
    NP_061362.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018874.2NP_061362.1  inactive pancreatic lipase-related protein 1 precursor

      See identical proteins and their annotated locations for NP_061362.1

      Status: PROVISIONAL

      Source sequence(s)
      AF061274
      Consensus CDS
      CCDS29931.1
      UniProtKB/Swiss-Prot
      O70478, Q5BKQ4, Q6NV82
      Related
      ENSMUSP00000045465.6, ENSMUST00000048644.6
      Conserved Domains (2) summary
      cd01759
      Location:356467
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
      pfam00151
      Location:18353
      Lipase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      58717319..58732601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)