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    POLD1 DNA polymerase delta 1, catalytic subunit [ Bos taurus (domestic cattle) ]

    Gene ID: 281990, updated on 27-Dec-2024

    Summary

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    Official Symbol
    POLD1provided by VGNC
    Official Full Name
    DNA polymerase delta 1, catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:33113
    See related
    Ensembl:ENSBTAG00000011083
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See POLD1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (56550417..56572345)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112442209 Neighboring gene nuclear receptor subfamily 1 group H member 2 Neighboring gene uncharacterized LOC132342718 Neighboring gene Spi-B transcription factor Neighboring gene myosin binding protein C2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Primary structure of the catalytic subunit of calf thymus DNA polymerase delta: sequence similarities with other DNA polymerases. Zhang J, et al. Biochemistry, 1991 Dec 24. PMID 1721537
    2. Identification of a fourth subunit of mammalian DNA polymerase delta. Liu L, et al. J Biol Chem, 2000 Jun 23. PMID 10751307
    3. Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme. Xie B, et al. Biochemistry, 2002 Nov 5. PMID 12403614
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication proofreading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in base-excision repair, gap-filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of delta DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase delta catalytic subunit
    Names
    3'-5' exodeoxyribonuclease
    DAN polymerase delta 1, catalytic subunit
    DNA-directed DNA polymerase delta 1
    polymerase (DNA directed), delta 1, catalytic subunit 125kDa
    NP_776852.1
    XP_024833715.1
    XP_059732494.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174427.2 → NP_776852.1  DNA polymerase delta catalytic subunit

      See identical proteins and their annotated locations for NP_776852.1

      Status: PROVISIONAL

      Source sequence(s)
      M80395
      UniProtKB/Swiss-Prot
      P28339
      UniProtKB/TrEMBL
      A0AAA9TFJ0
      Related
      ENSBTAP00000014714.7, ENSBTAT00000014714.7
      Conserved Domains (4) summary
      cd05777
      Location:303 → 532
      DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
      cd05533
      Location:578 → 973
      POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...
      PTZ00166
      Location:80 → 1099
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:1011 → 1081
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56550417..56572345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024977947.2 → XP_024833715.1  DNA polymerase delta catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0AAA9TFJ0
      Conserved Domains (1) summary
      cl10023
      Location:80 → 1075
      POLBc; DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic ...

    2. XM_059876511.1 → XP_059732494.1  DNA polymerase delta catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0AAA9TFJ0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28339.1 GenPept UniProtKB/Swiss-Prot:P28339

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