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    PCSK1 proprotein convertase subtilisin/kexin type 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281967, updated on 29-Jan-2025

    Summary

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    Official Symbol
    PCSK1provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 1provided by VGNC
    Primary source
    VGNC:VGNC:32646
    See related
    BGD:BT11120; Ensembl:ENSBTAG00000020843
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PC1; PC3
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (95746303..95790110, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107132664 Neighboring gene selenoprotein I pseudogene Neighboring gene uncharacterized LOC104968993 Neighboring gene uncharacterized LOC132345827 Neighboring gene calpastatin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The prohormone processing enzyme PC3 is a lipid raft-associated transmembrane protein. Arnaoutova I, et al. Biochemistry, 2003 Sep 9. PMID 12950171
    2. Differential regulation of gene expression of neurotensin and prohormone convertases PC1 and PC2 in the bovine ocular ciliary epithelium: possible implications on neurotensin processing. Ortego J, et al. Neurosci Lett, 2002 Nov 15. PMID 12401558
    3. Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2. Hwang SR, et al. DNA Cell Biol, 2000 Jul. PMID 10945231
    4. Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages. Li Q, et al. PLoS One, 2017. PMID 28902910, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prohormone convertase PC1 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.
      Title: Differential regulation of gene expression of neurotensin and prohormone convertases PC1 and PC2 in the bovine ocular ciliary epithelium: possible implications on neurotensin processing.
    2. a model of the membrane topology of the prohomone convertase PC3, where it is anchored to lipid rafts in secretory granule membranes via the transmembrane domain
      Title: The prohormone processing enzyme PC3 is a lipid raft-associated transmembrane protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuroendocrine convertase 1
    Names
    NEC 1
    prohormone convertase 1
    prohormone convertase 3
    proprotein convertase 1
    NP_776837.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174412.2 → NP_776837.1  neuroendocrine convertase 1 precursor

      See identical proteins and their annotated locations for NP_776837.1

      Status: PROVISIONAL

      Source sequence(s)
      AF186405
      UniProtKB/Swiss-Prot
      Q9GLR1
      UniProtKB/TrEMBL
      A0AAA9STT1
      Related
      ENSBTAP00070000447.1, ENSBTAT00070000724.1
      Conserved Domains (5) summary
      cd04059
      Location:121 → 415
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:158 → 432
      Peptidase_S8; Subtilase family
      pfam01483
      Location:504 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam12177
      Location:715 → 751
      Proho_convert; Prohormone convertase enzyme
      pfam16470
      Location:34 → 110
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      95746303..95790110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GLR1.1 GenPept UniProtKB/Swiss-Prot:Q9GLR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials