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    SDHD succinate dehydrogenase complex subunit D [ Bos taurus (domestic cattle) ]

    Gene ID: 281481, updated on 1-Jan-2025

    Summary

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    Official Symbol
    SDHDprovided by VGNC
    Official Full Name
    succinate dehydrogenase complex subunit Dprovided by VGNC
    Primary source
    VGNC:VGNC:110065
    See related
    Ensembl:ENSBTAG00000016266
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CII4; QPs3; cybS; CII-4
    Orthologs
    human mouse all
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    Genomic context

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    See SDHD in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (22397456..22409059)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene PIH1 domain containing 2 Neighboring gene NKAP domain containing 1 Neighboring gene translocase of inner mitochondrial membrane 8 homolog B Neighboring gene ATM interactor-like Neighboring gene interleukin 18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The smallest membrane anchoring subunit (QPs3) of bovine heart mitochondrial succinate-ubiquinone reductase. Cloning, sequencing, topology, and Q-binding domain. Shenoy SK, et al. J Biol Chem, 1997 Jul 11. PMID 9211943
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables succinate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquinone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, succinate to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
    Names
    malate dehydrogenase [quinone] cytochrome b small subunit
    succinate dehydrogenase complex, subunit D, integral membrane protein
    succinate-ubiquinone reductase membrane anchor subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174179.2 → NP_776604.1  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_776604.1

      Status: PROVISIONAL

      Source sequence(s)
      U50987
      UniProtKB/Swiss-Prot
      Q3T0U6, Q5UAB3, Q95123
      Related
      ENSBTAP00000021636.6, ENSBTAT00000021636.7
      Conserved Domains (1) summary
      cd03496
      Location:59 → 157
      SQR_TypeC_CybS; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Eukaryotic SQRs reduce high potential quinones such as ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22397456..22409059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024974988.2 → XP_024830756.1  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0AAA9STC4, B8Y899
      Related
      ENSBTAP00000089674.1, ENSBTAT00000097527.1
      Conserved Domains (1) summary
      cd03496
      Location:85 → 183
      SQR_TypeC_CybS; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Eukaryotic SQRs reduce high potential quinones such as ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric ...

    2. XM_024974989.2 → XP_024830757.1  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0AAA9TR76
      Related
      ENSBTAP00000100870.1, ENSBTAT00000110541.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95123.2 GenPept UniProtKB/Swiss-Prot:Q95123

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