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    Gfpt2 glutamine fructose-6-phosphate transaminase 2 [ Mus musculus (house mouse) ]

    Gene ID: 14584, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gfpt2provided by MGI
    Official Full Name
    glutamine fructose-6-phosphate transaminase 2provided by MGI
    Primary source
    MGI:MGI:1338883
    See related
    Ensembl:ENSMUSG00000020363 AllianceGenome:MGI:1338883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GFAT2
    Summary
    Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is expressed in craniocervical region bone; naris; and sternum. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GFPT2 (glutamine-fructose-6-phosphate transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 15.4), subcutaneous fat pad adult (RPKM 9.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gfpt2 in Genome Data Viewer
    Location:
    11 B1.2; 11 29.9 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49684981..49729448)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49794155..49838620)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 6 Neighboring gene STARR-positive B cell enhancer ABC_E9822 Neighboring gene predicted gene 12192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49538288-49538489 Neighboring gene predicted gene, 36411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49578193-49578302 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49585761-49585914 Neighboring gene STARR-seq mESC enhancer starr_29382 Neighboring gene predicted gene, 36507 Neighboring gene STARR-seq mESC enhancer starr_29384 Neighboring gene STARR-positive B cell enhancer ABC_E5221 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene predicted gene, 53699 Neighboring gene RasGEF domain family, member 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linked β-N-Acetylglucosaminylation and Attenuate Inflammation in Macrophages. Al-Mukh H, et al. J Immunol, 2020 Nov 1. PMID 32978282
    2. Cloning and characterization of mouse glutamine:fructose-6-phosphate amidotransferase 2 gene promoter. Yamazaki K, et al. Gene, 2000 Dec 31. PMID 11167021
    3. Cloning and partial characterization of the mouse glutamine:fructose-6-phosphate amidotransferase (GFAT) gene promoter. Sayeski PP, et al. Nucleic Acids Res, 1997 Apr 1. PMID 9060444, Free PMC Article
    4. Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. Dai W, et al. Biochim Biophys Acta Mol Basis Dis, 2018 Dec. PMID 30254013, Free PMC Article
    5. Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity. Hu Y, et al. J Biol Chem, 2004 Jul 16. PMID 15133036

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linked beta-N-Acetylglucosaminylation and Attenuate Inflammation in Macrophages.
      Title: Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linked β-N-Acetylglucosaminylation and Attenuate Inflammation in Macrophages.
    2. These results support a model wherein high fat diet increases retinal protein O-GlcNAcylation by promoting NR4A1-dependent GFAT2 expression.
      Title: Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression.
    3. mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) is phosphorylated by cAMP-dependent protein kinase, which increases the enzyme activity
      Title: Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate derivative binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glutamine metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
    Names
    D-fructose-6-phosphate amidotransferase 2
    GFAT 2
    glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2
    glutamine:fructose-6-phosphate amidotransferase 2
    hexosephosphate aminotransferase 2
    NP_038557.1
    XP_036012229.1
    XP_036012230.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013529.3 → NP_038557.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

      See identical proteins and their annotated locations for NP_038557.1

      Status: VALIDATED

      Source sequence(s)
      AK132821, BE198515, BM204562, CJ163487, DY247913
      Consensus CDS
      CCDS24622.1
      UniProtKB/Swiss-Prot
      Q5NCL2, Q9Z2Z9
      UniProtKB/TrEMBL
      Q3V0X4
      Related
      ENSMUSP00000020629.5, ENSMUST00000020629.5
      Conserved Domains (4) summary
      PLN02981
      Location:1 → 682
      PLN02981; glucosamine:fructose-6-phosphate aminotransferase
      cd00714
      Location:2 → 285
      GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...
      cd05008
      Location:369 → 494
      SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
      cd05009
      Location:526 → 680
      SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49684981..49729448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156337.1 → XP_036012230.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X2

      Conserved Domains (1) summary
      PLN02981
      Location:1 → 428
      PLN02981; glucosamine:fructose-6-phosphate aminotransferase

    2. XM_036156336.1 → XP_036012229.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X1

      UniProtKB/TrEMBL
      Q3V0X4
      Conserved Domains (1) summary
      PLN02981
      Location:2 → 675
      PLN02981; glucosamine:fructose-6-phosphate aminotransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2Z9.3 GenPept UniProtKB/Swiss-Prot:Q9Z2Z9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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