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    POU1F1 POU class 1 homeobox 1 [ Sus scrofa (pig) ]

    Gene ID: 397325, updated on 17-Aug-2024

    Summary

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    Official Symbol
    POU1F1provided by VGNC
    Official Full Name
    POU class 1 homeobox 1provided by VGNC
    Primary source
    VGNC:VGNC:108685
    See related
    Ensembl:ENSSSCG00000011996
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    Pit1; GHF-1; PIT-1; PIT-I
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human mouse all
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    Genomic context

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    See POU1F1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (168510671..168530394)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (179453195..179469328)

    Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 1F Neighboring gene uncharacterized LOC110256256 Neighboring gene charged multivesicular body protein 2B Neighboring gene vestigial like family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. The effect of a MspI polymorphism at the porcine pituitary specific transcription factor (PIT-1) gene on backfat thickness. De Smet S, et al. Commun Agric Appl Biol Sci, 2003. PMID 24757815
    2. PIT1 gene polymorphism in Pietrain and Large White pigs after divergent selection. Silveira AC, et al. Genet Mol Res, 2009 Aug 18. PMID 19731221
    3. Cloning and restriction fragment length polymorphism analysis of a cDNA for swine PIT-1, a gene controlling growth hormone expression. Tuggle CK, et al. Anim Genet, 1993 Feb. PMID 8098921
    4. Expression pattern, genomic cloning and RFLP analyses of the swine PIT-1 gene. Yu TP, et al. Anim Genet, 1994 Aug. PMID 7985839
    5. Polymorphisms in intron 1 of the porcine POU1F1 gene. Song CY, et al. J Appl Genet, 2007. PMID 17998594

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The association between a MspI polymorphism in the porcine PIT-1 gene and backfat thickness in Belgian slaughter pigs was confirmed in a number of breeds. In crossbred progeny the MspI D allele could possibly be associated with a higher backfat thickness.
      Title: The effect of a MspI polymorphism at the porcine pituitary specific transcription factor (PIT-1) gene on backfat thickness.
    2. The polymorphisms in the PIT1 gene of 103 pigs were examined and their frequencies in the maternal and paternal lineages of the Pietrain and Large White breeds, were compared.
      Title: PIT1 gene polymorphism in Pietrain and Large White pigs after divergent selection.
    3. paper demonstrated that the genetic variation in intron 1 of the POU1F1 (Pit1) gene was high and these polymorphisms may provide useful makers for QTL analysis
      Title: Polymorphisms in intron 1 of the porcine POU1F1 gene.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pituitary-specific positive transcription factor 1
    Names
    POU-domain protein
    POU-domain transcriptional regulator
    growth hormone factor 1
    pituitary-specific transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214163.1 → NP_999328.1  pituitary-specific positive transcription factor 1

      See identical proteins and their annotated locations for NP_999328.1

      Status: PROVISIONAL

      Source sequence(s)
      AF016251
      UniProtKB/Swiss-Prot
      O18807, O46410, Q04788
      UniProtKB/TrEMBL
      A0A8D0Q633, D9ZNP5
      Conserved Domains (2) summary
      smart00352
      Location:124 → 198
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:217 → 270
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

      Range
      168510671..168530394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021068539.1 → XP_020924198.1  pituitary-specific positive transcription factor 1 isoform X2

      UniProtKB/Swiss-Prot
      O18807, O46410, Q04788
      Conserved Domains (2) summary
      smart00352
      Location:147 → 221
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:240 → 293
      Homeobox; Homeobox domain

    2. XM_005657130.3 → XP_005657187.1  pituitary-specific positive transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      O18807, O46410, Q04788
      UniProtKB/TrEMBL
      A0A4X1UP07, A0A8D1CKF7, F6Q7Q0
      Related
      ENSSSCP00000012779.2, ENSSSCT00000013125.3
      Conserved Domains (2) summary
      smart00352
      Location:150 → 224
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:243 → 296
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04788.3 GenPept UniProtKB/Swiss-Prot:Q04788

    Gene LinkOut

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