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    RNF187 ring finger protein 187 [ Homo sapiens (human) ]

    Gene ID: 149603, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RNF187provided by HGNC
    Official Full Name
    ring finger protein 187provided by HGNC
    Primary source
    HGNC:HGNC:27146
    See related
    Ensembl:ENSG00000168159 MIM:613754; AllianceGenome:HGNC:27146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RACO1; RACO-1
    Summary
    Enables ubiquitin-protein transferase activity. Involved in positive regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 54.8), brain (RPKM 49.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF187 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228487382..228496188)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227675881..227684688)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228675083..228683889)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 4666a Neighboring gene H2B clustered histone 27, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228658552-228659062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228663712-228664547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228673961-228674822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228674823-228675683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228675801-228676529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228676530-228677257 Neighboring gene Sharpr-MPRA regulatory region 4602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228680575-228681520 Neighboring gene Sharpr-MPRA regulatory region 4759 Neighboring gene uncharacterized LOC105373124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228698839-228699340 Neighboring gene butyrophilin like 10, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:228736353-228737022 Neighboring gene RNA, 5S ribosomal pseudogene 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Immune infiltration is associated with pan-cancer prognostic biomarker RING finger protein 187. Fan XT, et al. J Mol Recognit, 2024 Mar. PMID 38167828
    2. RNF187 is Downregulated Following NF-κB Inhibition in Late Erythroblasts. Forster L, et al. Biochem Genet, 2016 Oct. PMID 27259582
    3. RING finger protein 187 as a novel potential biomarker for predicting the prognosis of ovarian carcinoma in 2 cancer centers. Chen J, et al. Curr Probl Cancer, 2020 Oct. PMID 32057463
    4. Overexpression of RNF187 induces cell EMT and apoptosis resistance in NSCLC. Fu Z, et al. J Cell Physiol, 2019 Aug. PMID 30624778
    5. RACO-1 modulates Hippo signalling in oesophageal squamous cell carcinoma. Pang D, et al. J Cell Mol Med, 2020 Oct. PMID 32896069, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immune infiltration is associated with pan-cancer prognostic biomarker RING finger protein 187.
      Title: Immune infiltration is associated with pan-cancer prognostic biomarker RING finger protein 187.
    2. Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187.
      Title: Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187.
    3. RING finger protein 187 as a novel potential biomarker for predicting the prognosis of ovarian carcinoma in 2 cancer centers.
      Title: RING finger protein 187 as a novel potential biomarker for predicting the prognosis of ovarian carcinoma in 2 cancer centers.
    4. RACO-1 modulates Hippo signalling in oesophageal squamous cell carcinoma.
      Title: RACO-1 modulates Hippo signalling in oesophageal squamous cell carcinoma.
    5. elevated RNF187 expression promotes NSCLC development by inducing cell EMT and apoptosis resistance, and RNF187 may be a novel prognostic indicator for NSCLC patients after curative resection
      Title: Overexpression of RNF187 induces cell EMT and apoptosis resistance in NSCLC.
    6. we identified that RNF187 is an essential factor for Notch1 to promote invasion and metastasis of HCC. Of highly clinical relevance, we found that activation of Notch1-RNF187 correlates with a worse prognosis of HCC patients.
      Title: An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma.
    7. Arginine methylation of RACO-1 is required for efficient transcriptional activation by c-Jun/AP-1 and thus identify PRMT1 as an important regulator of c-Jun/AP-1 function.
      Title: Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.
    8. The RACO-1(RING domain AP-1 co-activator-1) is a co-activator that links c-Jun to growth factor signalling and is essential for AP-1 function in proliferation
      Title: Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF187
    Names
    RING domain AP1 coactivator 1
    RING-type E3 ubiquitin transferase RNF187
    protein RNF187
    ring domain AP-1 co-activator 1
    NP_001010858.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010858.3 → NP_001010858.2  E3 ubiquitin-protein ligase RNF187

      Status: VALIDATED

      Source sequence(s)
      AL139288, BC012758, BI551408
      Consensus CDS
      CCDS76271.1
      UniProtKB/Swiss-Prot
      A6NL57, Q5TA31, Q6P2J7, Q6PJR0
      UniProtKB/TrEMBL
      A0A1X7SBW3
      Related
      ENSP00000306396.9, ENST00000305943.9
      Conserved Domains (1) summary
      pfam00097
      Location:12 → 52
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      228487382..228496188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654708.1 Reference GRCh38.p14 PATCHES

      Range
      78581..87387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      227675881..227684688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TA31.2 GenPept UniProtKB/Swiss-Prot:Q5TA31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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