GATAe GATAe [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GATAeprovided by FlyBase
Official Full Name: GATAeprovided by FlyBase
Primary source: FLYBASE:FBgn0038391
Locus tag: Dmel_CG10278
See related: AllianceGenome:FB:FBgn0038391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10278; CG10278-PA; dGATA-E; dGATAe; Dmel\CG10278
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including intestinal stem cell homeostasis; midgut development; and regulation of gene expression. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; adult epithelial cell; anterior endoderm; embryonic/larval midgut primordium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89A12-89A12; 3-58 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16009105..16019133)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11834827..11844855)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dGATAe and grn expression are independent of each other; dGATAe and grn are not responsible for setting the general embryonic midgut morphology; results clarify the expression patterns and function of the GATA factor genes expressed in the embryonic midgut
Title: GATA factor genes in the Drosophila midgut embryo.
We further demonstrate that JAK/STAT signaling, Sox21a and GATAe form a functional relay to orchestrate EB differentiation. Thus, our study provides new insights into the complex and sequential events that are required for rapid differentiation following stem cell division during tissue replenishment.
Title: A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila.
GATAe has pivotal roles in maintaining normal epithelial homeostasis of the Drosophila adult midgut through interaction of N signaling
Title: GATAe regulates intestinal stem cell maintenance and differentiation in Drosophila adult midgut.
Embryos with double-stranded RNA corresponding to dGATAe failed to express marker genes that are characteristic of differentiated midgut.
Title: An endoderm-specific GATA factor gene, dGATAe, is required for the terminal differentiation of the Drosophila endoderm.
GATAe activates a major subset of genes in the midgut, and some other pathway(s) downstream of srp activates other genes.
Title: GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GATAe

Names: CG10278-PA; CG10278-PB; CG10278-PC; GATAe-PA; GATAe-PB; GATAe-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

16009105..16019133

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202302.1 → NP_001189231.1 GATAe, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189231.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JDD2, Q9BPQ3

Conserved Domains (2) summary

smart00401
Location:519 → 568

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:523 → 574

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001202303.1 → NP_001189232.1 GATAe, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189232.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JDD2, Q9BPQ3

Conserved Domains (2) summary

smart00401
Location:519 → 568

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:523 → 574

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_142259.4 → NP_650516.2 GATAe, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650516.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9BPQ3, Q9VF00

Related

FBpp0082672

Conserved Domains (2) summary

smart00401
Location:534 → 583

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:538 → 589

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C