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    Wdfy2 WD repeat and FYVE domain containing 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34425, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdfy2provided by FlyBase
    Official Full Name
    WD repeat and FYVE domain containing 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032246
    Locus tag
    Dmel_CG5168
    See related
    AllianceGenome:FB:FBgn0032246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5168; Dmel\CG5168; WDFY2
    Summary
    Enables protein kinase binding activity. Located in endosome. Is expressed in adult head; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to human WDFY1 (WD repeat and FYVE domain containing 1) and WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wdfy2 in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10423291..10425482)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10423291..10425482)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Replication factor C subunit 3 Neighboring gene pineapple eye Neighboring gene Small ribonucleoprotein particle protein SmB Neighboring gene KDEL receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Environmental complexity and the purging of deleterious alleles. Singh A, et al. Evolution, 2017 Nov. PMID 28840604
    2. Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, et al. Nat Cell Biol, 2017 Dec. PMID 29084199
    3. A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Kim YO, et al. Proc Natl Acad Sci U S A, 2004 Jan 6. PMID 14684833, Free PMC Article
    4. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860
    5. A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling. Trivedi D, et al. Elife, 2020 Dec 15. PMID 33320085, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat and FYVE domain containing 2
    Names
    CG5168-PA
    CG5168-PB
    Wdfy2-PA
    Wdfy2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10423291..10425482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201850.1 → NP_001188779.1  WD repeat and FYVE domain containing 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188779.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKW1
      Conserved Domains (4) summary
      COG2319
      Location:4 → 405
      WD40; WD40 repeat [General function prediction only]
      cd15718
      Location:287 → 356
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:166 → 205
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:24 → 279
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_135556.4 → NP_609400.1  WD repeat and FYVE domain containing 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKW1
      Related
      FBpp0079610
      Conserved Domains (4) summary
      COG2319
      Location:4 → 405
      WD40; WD40 repeat [General function prediction only]
      cd15718
      Location:287 → 356
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:166 → 205
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:24 → 279
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKW1 Q9VKW1

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