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    CG7335 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40203, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7335provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036941
    Locus tag
    Dmel_CG7335
    See related
    AllianceGenome:FB:FBgn0036941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT09463; Dmel\CG7335
    Summary
    Predicted to enable ketohexokinase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; response to hexose; and response to insulin. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7335 in Genome Data Viewer
    Location:
    76F2-76F2; 3-46 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20132032..20133268, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20125132..20126368, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene obstructor-J Neighboring gene gigas Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Huichalaf CH, et al. Hum Mol Genet, 2019 Jun 15. PMID 30753434, Free PMC Article
    2. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
    3. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ketohexokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketohexokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ketohexokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to fructose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to insulin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to sucrose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7335-PA
    NP_649180.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20132032..20133268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140923.2 → NP_649180.1  uncharacterized protein Dmel_CG7335 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0HDP3, Q9VW82
      Related
      FBpp0074634
      Conserved Domains (1) summary
      cd01939
      Location:32 → 357
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3Q7 Q8T3Q7
    Q9VW82 Q9VW82

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