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    ubc ubiquitin C [ Danio rerio (zebrafish) ]

    Gene ID: 777766, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ubcprovided by ZNC
    Official Full Name
    ubiquitin Cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061110-88
    See related
    Ensembl:ENSDARG00000102632 AllianceGenome:ZFIN:ZDB-GENE-061110-88
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7042025; wu:fb37h06; zgc:153686
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBC (ubiquitin C). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ubc in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (44692226..44694736)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (44845614..44848124)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene seizure related 6 homolog like Neighboring gene tyrosylprotein sulfotransferase 2 Neighboring gene scavenger receptor class B, member 1 Neighboring gene uncharacterized LOC137496616 Neighboring gene tachykinin receptor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization and biological function analysis of the trim3a gene from zebrafish (Danio rerio). Zhang X, et al. Fish Shellfish Immunol, 2012 May. PMID 22300786
    2. RNA secondary structure profiling in zebrafish reveals unique regulatory features. Kaushik K, et al. BMC Genomics, 2018 Feb 15. PMID 29448945, Free PMC Article
    3. An optimized QF-binary expression system for use in zebrafish. Burgess J, et al. Dev Biol, 2020 Sep 15. PMID 32697972
    4. A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines for Functional Neuroanatomy Studies. Marquart GD, et al. Front Neural Circuits, 2015. PMID 26635538, Free PMC Article
    5. Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30. Sato Y, et al. Nat Struct Mol Biol, 2017 Nov. PMID 28945247

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polyubiquitin-C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077804.2 → NP_001071272.2  polyubiquitin-C

      Status: VALIDATED

      Source sequence(s)
      CU463283
      UniProtKB/TrEMBL
      A0A8M1NAS3, F1QHN6, Q6IS68
      Related
      ENSDARP00000139647.1, ENSDART00000157458.2
      Conserved Domains (2) summary
      cd01803
      Location:77 → 152
      Ubiquitin; Ubiquitin
      smart00213
      Location:1 → 72
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      44692226..44694736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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