U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Art4 Arginine methyltransferase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41219, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Art4provided by FlyBase
    Official Full Name
    Arginine methyltransferase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0037770
    Locus tag
    Dmel_CG5358
    See related
    AllianceGenome:FB:FBgn0037770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CARM1; CG5358; dArt 4; Dart4; DART4; Dmel\CG5358; PRMT4
    Summary
    Enables histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; and protein-arginine omega-N monomethyltransferase activity. Involved in positive regulation of ecdysone receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including embryonic/larval midgut primordium; female germline cell; ganglia; head epidermis primordium; and imaginal disc. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Art4 in Genome Data Viewer
    Location:
    85F4-85F4; 3-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9982816..9986060, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5808538..5811782, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tipE homolog 1 Neighboring gene long non-coding RNA:CR45029 Neighboring gene uncharacterized protein Neighboring gene Glucose transporter 4 enhancer factor Neighboring gene mir-9371 stem loop Neighboring gene Gustatory receptor 85a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tissue-dependent subcellular localization of Drosophila arginine methyl-transferase 4 (DART4), a coactivator whose overexpression affects neither viability nor differentiation. Urwyler O, et al. Differentiation, 2007 Oct. PMID 17459088
    2. Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor. Kimura S, et al. Biochem Biophys Res Commun, 2008 Jul 11. PMID 18468516
    3. LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes. Lv P, et al. Nat Commun, 2024 Apr 18. PMID 38637528, Free PMC Article
    4. The lncRNA hsrω regulates arginine dimethylation of human FUS to cause its proteasomal degradation in Drosophila. Lo Piccolo L, et al. J Cell Sci, 2019 Oct 23. PMID 31519807, Free PMC Article
    5. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Wang YC, et al. Mol Phylogenet Evol, 2015 Mar. PMID 25576770

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H3R17 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3R2 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3R2 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone arginine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine omega-N asymmetric methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-arginine omega-N monomethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-arginine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ecdysone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    arginine methyltransferase 4
    Names
    Art4-PA
    Art4-PB
    CARMER
    CG5358-PA
    CG5358-PB
    arginie methyl transferase 4
    arginine methyl-transferase 4
    coactivator Arg methyltransferase for Ecr/Usp
    NP_001262445.1
    NP_649963.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9982816..9986060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275516.1 → NP_001262445.1  arginine methyltransferase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NL6, Q9VH48
      UniProtKB/TrEMBL
      F0JAI1
      Conserved Domains (3) summary
      cd02440
      Location:183 → 281
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05185
      Location:53 → 430
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17171
      Location:24 → 134
      PH-like; Pleckstrin homology-like domain

    2. NM_141706.3 → NP_649963.1  arginine methyltransferase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NL6, Q9VH48
      UniProtKB/TrEMBL
      F0JAI1
      Related
      FBpp0081628
      Conserved Domains (3) summary
      cd02440
      Location:183 → 281
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05185
      Location:53 → 430
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17171
      Location:24 → 134
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F0JAI1 F0JAI1
    Q9VH48.1 Q9VH48

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous