Cygb cytoglobin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cygbprovided by MGI
Official Full Name: cytoglobinprovided by MGI
Primary source: MGI:MGI:2149481
See related: Ensembl:ENSMUSG00000020810 AllianceGenome:MGI:2149481
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HGb; Staap; 3110001K20Rik
Summary: Enables nitric oxide dioxygenase activity, heme protein as donor and superoxide dismutase activity. Involved in nitric oxide catabolic process and removal of superoxide radicals. Located in neuron projection; neuronal cell body; and nucleus. Is active in cytoplasm. Is expressed in several structures, including brain; genitourinary system; oral cavity; sensory organ; and tongue. Orthologous to human CYGB (cytoglobin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 60.4), ovary adult (RPKM 54.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 81.45 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116536421..116544887, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116645595..116654504, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain.
Title: Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain.
Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis.
Title: Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis.
Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes.
Title: Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes.
Defining the reducing system of the NO dioxygenase cytoglobin in vascular smooth muscle cells and its critical role in regulating cellular NO decay.
Title: Defining the reducing system of the NO dioxygenase cytoglobin in vascular smooth muscle cells and its critical role in regulating cellular NO decay.
we have shown that Cygb deficiency exacerbated AOM/DSS-induced inflammation and augmented the establishment of colonic tumors.
Title: Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.
Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and NOD activity of Cygb represents a strategy for the treatment of cardiovascular disease
Title: Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.
Expression of all fibrosis-related markers following bile duct ligation was significantly increased in Cygb(-/-) mice compared with wild-type mice. Cygb deficiency enhances hepatocyte damage and inflammation.
Title: Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice.
we identified CYGB as an important regulator of osteosarcoma (OS) extravasation and highlighted the importance of the LEF1-CYGB regulatory axis in OS metastasis to the lungs.
Title: Novel lymphoid enhancer-binding factor 1-cytoglobin axis promotes extravasation of osteosarcoma cells into the lungs.
This study demonstrated the role of CYGB in fibroblast cell motility and proliferation. CYGB could be a promising candidate for further studies as a potential target for diseases related to cell migration such as cancer and chronic wound treatment.
Title: Cytoglobin inhibits migration through PI3K/AKT/mTOR pathway in fibroblast cells.
Thus, the absence of Cygb in pericytes provokes organ abnormalities, possibly via derangement of the nitric oxide and antioxidant defence system and through accelerated cellular senescence.
Title: Absence of cytoglobin promotes multiple organ abnormalities in aged mice.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbon monoxide binding	IEA Inferred from Electronic Annotation more info
enables carbon monoxide binding	ISO Inferred from Sequence Orthology more info
enables catalase activity	IEA Inferred from Electronic Annotation more info
enables catalase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid peroxidase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid peroxidase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables nitric oxide dioxygenase activity, heme protein as donor	IDA Inferred from Direct Assay more info	PubMed
enables nitric oxide dioxygenase activity, heme protein as donor	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables superoxide dismutase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables superoxide dismutase activity	ISO Inferred from Sequence Orthology more info
enables superoxide dismutase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatic stellate cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hepatic stellate cell activation	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nitric oxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoglobin

Names: histoglobin; nitric oxygen dioxygenase; nitrite reductase CYGB; pseudoperoxidase CYGB; stellate cell activation associated protein; superoxide dismutase CYGB

NP_001405094.1

EC 1.15.1.1

NP_084482.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.