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    Rab9 RAB9, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 56382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab9provided by MGI
    Official Full Name
    RAB9, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1890695
    See related
    Ensembl:ENSMUSG00000079316 AllianceGenome:MGI:1890695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab9a; Sid6061p; 2410064E05Rik
    Summary
    Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation by host of symbiont catalytic activity; positive regulation of exocytosis; and retrograde transport, endosome to Golgi. Located in cytoplasmic vesicle membrane and melanosome. Orthologous to human RAB9A (RAB9A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 21.4), liver E18 (RPKM 14.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab9 in Genome Data Viewer
    Location:
    X F5; X 77.47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (165240247..165262863, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (166457251..166479867, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene glycoprotein m6b Neighboring gene OFD1, centriole and centriolar satellite protein Neighboring gene STARR-positive B cell enhancer ABC_E11806 Neighboring gene trafficking protein particle complex 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:162917789-162917898 Neighboring gene family with sequence similarity 154, member A pseudogene Neighboring gene predicted gene 15223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. Saito T, et al. J Clin Invest, 2019 Feb 1. PMID 30511961, Free PMC Article
    2. Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis. Mareninova OA, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 34610499, Free PMC Article
    3. Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart. Nah J, et al. Cardiovasc Res, 2022 Sep 20. PMID 35018428, Free PMC Article
    4. IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress. Xu C, et al. Redox Biol, 2024 May. PMID 38373380, Free PMC Article
    5. Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2. Zhang Z, et al. Structure, 2014 Oct 7. PMID 25220469

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.
      Title: IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.
    2. Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.
      Title: Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.
    3. Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
      Title: Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
    4. Mitophagy mediated through the Ulk1/Rab9/Rip1/Drp1 pathway protected the heart against ischemia by maintaining healthy mitochondria.
      Title: An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia.
    5. Crystal structure of the Rab9A-RUTBC2 Rab-binding domain complex reveals that the hypervariable region of Rab9A is not required for RUTBC2 binding.
      Title: Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation by host of symbiont catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in melanosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-9A
    Names
    SID 99
    rab-9A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019773.2 → NP_062747.1  ras-related protein Rab-9A

      See identical proteins and their annotated locations for NP_062747.1

      Status: VALIDATED

      Source sequence(s)
      AK017301, AL672174
      Consensus CDS
      CCDS30527.1
      UniProtKB/Swiss-Prot
      Q9R0M6
      UniProtKB/TrEMBL
      A2AFP5, Q0PD48
      Related
      ENSMUSP00000123325.2, ENSMUST00000112091.9
      Conserved Domains (1) summary
      cd04116
      Location:3 → 172
      Rab9; Rab GTPase family 9 (Rab9)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      165240247..165262863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162049.1 → XP_036017942.1  ras-related protein Rab-9A isoform X1

      UniProtKB/Swiss-Prot
      Q9R0M6
      UniProtKB/TrEMBL
      A2AFP5, Q0PD48
      Conserved Domains (1) summary
      cd04116
      Location:3 → 172
      Rab9; Rab GTPase family 9 (Rab9)

    2. XM_036162048.1 → XP_036017941.1  ras-related protein Rab-9A isoform X1

      UniProtKB/Swiss-Prot
      Q9R0M6
      UniProtKB/TrEMBL
      A2AFP5, Q0PD48
      Conserved Domains (1) summary
      cd04116
      Location:3 → 172
      Rab9; Rab GTPase family 9 (Rab9)

    3. XM_006528922.1 → XP_006528985.1  ras-related protein Rab-9A isoform X1

      See identical proteins and their annotated locations for XP_006528985.1

      UniProtKB/Swiss-Prot
      Q9R0M6
      UniProtKB/TrEMBL
      A2AFP5, Q0PD48
      Conserved Domains (1) summary
      cd04116
      Location:3 → 172
      Rab9; Rab GTPase family 9 (Rab9)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0M6.1 GenPept UniProtKB/Swiss-Prot:Q9R0M6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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