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    Prl3d1 prolactin family 3, subfamily d, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 18775, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prl3d1provided by MGI
    Official Full Name
    prolactin family 3, subfamily d, member 1provided by MGI
    Primary source
    MGI:MGI:97606
    See related
    Ensembl:ENSMUSG00000057170 AllianceGenome:MGI:97606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pl1; Csh1; Ghd4; PL-I; Pl-1; PL-Ia; mPL-I; PL-I-alpha
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Is expressed in several structures, including extraembryonic component and genitourinary system. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 74.8) See more
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    Genomic context

    See Prl3d1 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.27 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27278172..27284243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27094189..27100260)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27a-like Neighboring gene STARR-seq mESC enhancer starr_34013 Neighboring gene STARR-seq mESC enhancer starr_34014 Neighboring gene prolactin Neighboring gene prolactin family 3, subfamily d, member 1 Neighboring gene prolactin family 3, subfamily d, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC76481

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prolactin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prolactin-3D1
    Names
    chorionic somatomammotropin hormone 1
    growth hormone d4
    placental lactogen 1
    placental lactogen I
    placental lactogen-I alpha
    prolactin-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205322.1NP_001192251.1  prolactin-3D1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001192251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL591843
      Consensus CDS
      CCDS56874.1
      UniProtKB/Swiss-Prot
      P18121
      UniProtKB/TrEMBL
      A0A286YC78
      Related
      ENSMUSP00000152890.2, ENSMUST00000225330.2
      Conserved Domains (1) summary
      cd10288
      Location:25224
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
    2. NM_008864.3NP_032890.2  prolactin-3D1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_032890.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK082929, AL591843, CJ214787
      Consensus CDS
      CCDS88428.1
      UniProtKB/TrEMBL
      Q5SY42, Q6P244, Q8BNL4, Q8CGZ6
      Related
      ENSMUSP00000080731.5, ENSMUST00000082079.5
      Conserved Domains (1) summary
      cd10288
      Location:24223
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27278172..27284243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)