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    CDC3 septin CDC3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851024, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDC3
    Official Full Name
    septin CDC3
    Primary source
    SGD:S000004306
    Locus tag
    YLR314C
    See related
    AllianceGenome:SGD:S000004306; FungiDB:YLR314C; VEuPathDB:YLR314C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTP binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. A structural constituent of cytoskeleton. Involved in mitotic cytokinesis; septin ring assembly; and septin ring disassembly. Located in several cellular components, including mating projection base; prospore membrane; and septin cytoskeleton. Part of septin complex. Orthologous to several human genes including SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CDC3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (762575..764137, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL15 Neighboring gene Sph1p Neighboring gene Nkp2p Neighboring gene Tad3p Neighboring gene telomerase reverse transcriptase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation. Baumann S, et al. EMBO Rep, 2014 Jan. PMID 24355572, Free PMC Article
    2. Tension modulates actin filament polymerization mediated by formin and profilin. Courtemanche N, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716666, Free PMC Article
    3. Formation of septum-like structures at locations remote from the budding sites in cytokinesis-defective mutants of Saccharomyces cerevisiae. Slater ML, et al. J Bacteriol, 1985 May. PMID 3886632, Free PMC Article
    4. Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals. DeMay BS, et al. J Cell Biol, 2011 Jun 13. PMID 21670216, Free PMC Article
    5. Structural insights into yeast septin organization from polarized fluorescence microscopy. Vrabioiu AM, et al. Nature, 2006 Sep 28. PMID 17006515

    See all (172) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Local mRNA translation loads endosomes with Cdc3 for assembly and efficient delivery to septin filaments.
      Title: Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation.
    2. Data indicate that small forces on the filaments dramatically slowed formin Bni1p-mediated polymerization in the absence of profilin, but resulted in faster polymerization in the presence of profilin.
      Title: Tension modulates actin filament polymerization mediated by formin and profilin.
    3. Both the hourglass and ring filament assemblies have sub-resolution C(2) symmetry and lack net polarity along the mother-daughter axis.
      Title: Symmetry of septin hourglass and ring structures.
    4. during cytokinesis septin rings, located on both sides of the actomyosin ring, acted as barriers to compartmentalize the cortex around the cleavage site
      Title: Spatial coordination of cytokinetic events by compartmentalization of the cell cortex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ascospore wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of septin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in septin filament array IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin CDC3
    NP_013418.2
    • Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      762575..764137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182203.2 → NP_013418.2  TPA: septin CDC3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013418.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYV8, P32457, Q06161
      UniProtKB/TrEMBL
      A7A1J9, B3RHJ2, B5VNL3, G2WJD7
      Conserved Domains (1) summary
      COG5019
      Location:97 → 503
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32457.3

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