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    GAL3ST4 galactose-3-O-sulfotransferase 4 [ Homo sapiens (human) ]

    Gene ID: 79690, updated on 27-Nov-2024

    Summary

    Official Symbol
    GAL3ST4provided by HGNC
    Official Full Name
    galactose-3-O-sulfotransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:24145
    See related
    Ensembl:ENSG00000197093 MIM:608235; AllianceGenome:HGNC:24145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAL3ST-4
    Summary
    This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 11.3), salivary gland (RPKM 5.3) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GAL3ST4 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100159244..100168617, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101399037..101408410, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99756867..99766240, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99746769-99747381 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99755453-99755629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18420 Neighboring gene trafficking protein particle complex subunit 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99757927-99758426 Neighboring gene microRNA 4658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18424 Neighboring gene glypican 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18425 Neighboring gene STAG3 cohesin complex component Neighboring gene 60S ribosomal protein L29-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: GPC2

    Clone Names

    • FLJ12116

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    galactose-3-O-sulfotransferase 4
    Names
    beta-galactose-3-O-sulfotransferase 4
    gal-beta-1,3-GalNAc 3'-sulfotransferase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024637.5NP_078913.3  galactose-3-O-sulfotransferase 4

      See identical proteins and their annotated locations for NP_078913.3

      Status: REVIEWED

      Source sequence(s)
      AC073842, AF316113
      Consensus CDS
      CCDS5688.1
      UniProtKB/Swiss-Prot
      A4D2A8, B4DWL8, D6W5U5, Q8N3P7, Q8WZ17, Q96E33, Q96RP7, Q9HA78
      UniProtKB/TrEMBL
      B3KRX9
      Related
      ENSP00000353142.4, ENST00000360039.9
      Conserved Domains (1) summary
      cl22970
      Location:18469
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100159244..100168617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101399037..101408410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)