AFDN afadin, adherens junction formation factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: AFDNprovided by HGNC
Official Full Name: afadin, adherens junction formation factorprovided by HGNC
Primary source: HGNC:HGNC:7137
See related: Ensembl:ENSG00000130396 MIM:159559; AllianceGenome:HGNC:7137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AF6; MLLT4; MLL-AF6; l-afadin
Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
Expression: Ubiquitous expression in esophagus (RPKM 18.5), lung (RPKM 15.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q27

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (167826564..167972023)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (169164770..169309528)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (168227244..168372703)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate.
Title: Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate.
[Clinical characteristics and prognosis of MLL-AF6 positive patients with acute myeloid leukemia].
Title: [Clinical characteristics and prognosis of MLL-AF6 positive patients with acute myeloid leukemia].
Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.
Title: Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.
Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles.
Title: Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles.
Afadin binding with interaction partners in adipocytes, among which HDAC6 preferentially interacts with phosphorylated Afadin and acts as a key intermediate to suppress insulin receptor protein levels.
Title: Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.
The authors report here that the homophilic receptor PTPRK is stabilized at cell-cell contacts in epithelial cells. PTPRK directly and selectively dephosphorylates at least five substrates, including Afadin, PARD3 and delta-catenin family members, which are all important cell-cell adhesion regulators.
Title: The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion.
high levels of both Claudin-2 and Afadin in primary tumors were associated with poor disease-specific survival, relapse-free survival, lung-specific relapse, and liver-specific relapse
Title: Afadin cooperates with Claudin-2 to promote breast cancer metastasis.
CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells.
Title: CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231.
AF6 employs a non-canonical, evolutionarily conserved alpha-helix to bind RAS, unique to AF6 and the classical RASSF effectors.
Title: Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
miR-188-3p is a novel independent prognostic factor in colorectal cancer patients, which can be partly explained by its effect on MLLT4 expression and migration of cancer cells.
Title: Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Cellular biotinylated myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 (MLLT4, Afadin) protein is incorporated into HIV-1 Gag virus-like particles	PubMed
Tat	tat	The expression of MLLT4 gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-U02478 (e-PCR)
- UniSTS:29712

AL034440 (e-PCR)
- UniSTS:94231

SHGC-34245 (e-PCR)
- UniSTS:11803

SHGC-106814 (e-PCR)
- UniSTS:170038

D6S1539 (e-PCR)
- UniSTS:50002

STS-R33112 (e-PCR)
- UniSTS:42857

RH80394 (e-PCR)
- UniSTS:85354

RH122318 (e-PCR)
- UniSTS:137841

SHGC-143407 (e-PCR)
- UniSTS:171902

RH45127 (e-PCR)
- UniSTS:12681

G29377 (e-PCR)
- UniSTS:8589

RH103088 (e-PCR)
- UniSTS:97422

D1S3695 (e-PCR)
- UniSTS:474273

RH75081 (e-PCR)
- UniSTS:89291

AL035180 (e-PCR)
- UniSTS:94671

WI-11462 (e-PCR)
- UniSTS:68309

RH69394 (e-PCR)
- UniSTS:52707

RH12549 (e-PCR)
- UniSTS:68345

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in establishment of endothelial intestinal barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
part_of pore complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: afadin

Names: ALL1-fused gene from chromosome 6 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; protein AF-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029689.2 RefSeqGene

Range

4921..150033

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001040000.3 → NP_001035089.1 afadin isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has several differences compared to variant 4. The resulting isoform (2) is longer at the N-terminus but has a shorter and distinct C-terminus compared to isoform 4.

Source sequence(s)

AB209420, AI271860, AK055689, AL009178, BE503462, D60168

Consensus CDS

CCDS47517.1

UniProtKB/TrEMBL

Q5TIG5

Related

ENSP00000375956.3, ENST00000392108.7

Conserved Domains (5) summary

cd01781
Location:247 → 346

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 → 131

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 932

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:1008 → 1090

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001207008.2 → NP_001193937.1 afadin isoform 1

See identical proteins and their annotated locations for NP_001193937.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) has multiple differences compared to variant 4. The resulting isoform (1, also known as AF6i3) contains a C-terminal F-actin-binding site and has been shown to be involved in the regulation of epithelial wound closure and intercellular adhesion (PMID:16882694).

Source sequence(s)

AB209420, AL009178, AL049698, AL161973, BE645141, DA200453, DB079271

Consensus CDS

CCDS75553.1

UniProtKB/TrEMBL

G1UI22

Related

ENSP00000375960.2, ENST00000392112.5

Conserved Domains (5) summary

cd01781
Location:246 → 345

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 → 131

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

cd00060
Location:383 → 483

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00992
Location:991 → 1073

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:595 → 916

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
NM_001291964.2 → NP_001278893.1 afadin isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).

Source sequence(s)

AB621809, AL009178, AL049698, AL161973

Consensus CDS

CCDS78199.1

UniProtKB/TrEMBL

A8MQ02, G1UI22

Related

ENSP00000355771.3, ENST00000366806.6

Conserved Domains (5) summary

cd01781
Location:206 → 305

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd00060
Location:376 → 458

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:570 → 891

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:967 → 1049

PDZ; PDZ domain (Also known as DHR or GLGF)

cl00155
Location:1 → 90

UBQ; Ubiquitin-like proteins
NM_001366319.2 → NP_001353248.1 afadin isoform 5

Status: REVIEWED

Source sequence(s)

AL009178, AL049698, KT258903

UniProtKB/TrEMBL

A0A1P7ZIN0, G1UI22

Conserved Domains (6) summary

cd01781
Location:247 → 346

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 → 131

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 932

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:1008 → 1090

PDZ; PDZ domain (Also known as DHR or GLGF)

cl25548
Location:1517 → 1678

DUF4670; Domain of unknown function (DUF4670)
NM_001366320.2 → NP_001353249.1 afadin isoform 6

Status: REVIEWED

Source sequence(s)

AL009178, AL049698, AL731868

Consensus CDS

CCDS94034.1

UniProtKB/Swiss-Prot

O75087, O75088, O75089, P55196, Q59FP0, Q5TIG6, Q5TIG7, Q9NSN7, Q9NU92

UniProtKB/TrEMBL

G1UI22

Related

ENSP00000404595.2, ENST00000447894.6

Conserved Domains (6) summary

cd01781
Location:247 → 346

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 → 131

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 932

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:1008 → 1090

PDZ; PDZ domain (Also known as DHR or GLGF)

cl25548
Location:1517 → 1680

DUF4670; Domain of unknown function (DUF4670)
NM_001366321.2 → NP_001353250.1 afadin isoform 7

Status: REVIEWED

Source sequence(s)

AL009178, AL049698, AL731868

UniProtKB/TrEMBL

G1UI22

Conserved Domains (6) summary

cd01781
Location:248 → 347

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 → 132

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

cd00060
Location:385 → 485

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:597 → 925

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:1001 → 1083

PDZ; PDZ domain (Also known as DHR or GLGF)

cl25548
Location:1510 → 1673

DUF4670; Domain of unknown function (DUF4670)
NM_001386888.1 → NP_001373817.1 afadin isoform 8

Status: REVIEWED

Source sequence(s)

AL009178, AL049698, AL731868

Consensus CDS

CCDS94033.1

UniProtKB/TrEMBL

A0A804HJ20, G1UI22

Related

ENSP00000507324.1, ENST00000683244.1

Conserved Domains (6) summary

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 939

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:247 → 347

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1015 → 1097

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15709
Location:1469 → 1687

DUF4670; Domain of unknown function (DUF4670)
NM_001410951.1 → NP_001397880.1 afadin isoform 9

Status: REVIEWED

Source sequence(s)

AL009178, AL049698, AL731868

Consensus CDS

CCDS94035.1

UniProtKB/TrEMBL

G1UI22, J3KN01

Related

ENSP00000252692.6, ENST00000351017.9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

167826564..167972023

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418788.1 → XP_047274744.1 afadin isoform X1

UniProtKB/TrEMBL

H0Y8U8
XM_047418789.1 → XP_047274745.1 afadin isoform X2

UniProtKB/TrEMBL

H0Y8U8
XM_017010878.2 → XP_016866367.1 afadin isoform X27

UniProtKB/TrEMBL

G1UI22
XM_006715491.3 → XP_006715554.1 afadin isoform X45

UniProtKB/TrEMBL

G1UI22

Conserved Domains (5) summary

cd01781
Location:248 → 347

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 → 132

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 940

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:1016 → 1098

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047418790.1 → XP_047274746.1 afadin isoform X3

UniProtKB/TrEMBL

H0Y8U8
XM_047418791.1 → XP_047274747.1 afadin isoform X4

UniProtKB/TrEMBL

H0Y8U8
XM_047418814.1 → XP_047274770.1 afadin isoform X28

UniProtKB/TrEMBL

G1UI22
XM_047418792.1 → XP_047274748.1 afadin isoform X5

UniProtKB/TrEMBL

H0Y8U8
XM_047418793.1 → XP_047274749.1 afadin isoform X6

UniProtKB/TrEMBL

H0Y8U8
XM_017010882.2 → XP_016866371.1 afadin isoform X29

UniProtKB/TrEMBL

G1UI22
XM_047418794.1 → XP_047274750.1 afadin isoform X7

UniProtKB/TrEMBL

H0Y8U8
XM_005266997.3 → XP_005267054.1 afadin isoform X31

UniProtKB/TrEMBL

G1UI22

Conserved Domains (5) summary

cd01781
Location:248 → 347

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 → 132

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 933

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:1009 → 1091

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047418796.1 → XP_047274752.1 afadin isoform X9

UniProtKB/TrEMBL

H0Y8U8
XM_047418798.1 → XP_047274754.1 afadin isoform X11

UniProtKB/TrEMBL

H0Y8U8
XM_047418800.1 → XP_047274756.1 afadin isoform X13

UniProtKB/TrEMBL

H0Y8U8
XM_047418818.1 → XP_047274774.1 afadin isoform X34

UniProtKB/TrEMBL

G1UI22
XM_047418801.1 → XP_047274757.1 afadin isoform X14

UniProtKB/TrEMBL

H0Y8U8
XM_047418804.1 → XP_047274760.1 afadin isoform X17

UniProtKB/TrEMBL

H0Y8U8
XM_047418821.1 → XP_047274777.1 afadin isoform X37

UniProtKB/TrEMBL

G1UI22
XM_047418805.1 → XP_047274761.1 afadin isoform X18

UniProtKB/TrEMBL

H0Y8U8
XM_047418811.1 → XP_047274767.1 afadin isoform X24

UniProtKB/TrEMBL

H0Y8U8
XM_047418824.1 → XP_047274780.1 afadin isoform X41

UniProtKB/TrEMBL

G1UI22
XM_047418815.1 → XP_047274771.1 afadin isoform X30

UniProtKB/TrEMBL

G1UI22
XM_047418797.1 → XP_047274753.1 afadin isoform X10

UniProtKB/TrEMBL

H0Y8U8

Related

ENSP00000422166.3, ENST00000515794.3
XM_047418816.1 → XP_047274772.1 afadin isoform X32

UniProtKB/TrEMBL

G1UI22
XM_047418820.1 → XP_047274776.1 afadin isoform X36

UniProtKB/TrEMBL

G1UI22
XM_047418802.1 → XP_047274758.1 afadin isoform X15

UniProtKB/TrEMBL

H0Y8U8
XM_047418808.1 → XP_047274764.1 afadin isoform X21

UniProtKB/TrEMBL

H0Y8U8
XM_047418823.1 → XP_047274779.1 afadin isoform X39

UniProtKB/TrEMBL

G1UI22
XM_047418810.1 → XP_047274766.1 afadin isoform X23

UniProtKB/TrEMBL

H0Y8U8
XM_047418813.1 → XP_047274769.1 afadin isoform X26

UniProtKB/TrEMBL

H0Y8U8
XM_047418826.1 → XP_047274782.1 afadin isoform X43

UniProtKB/TrEMBL

G1UI22
XM_047418795.1 → XP_047274751.1 afadin isoform X8

UniProtKB/TrEMBL

H0Y8U8
XM_047418819.1 → XP_047274775.1 afadin isoform X35

UniProtKB/TrEMBL

G1UI22
XM_047418803.1 → XP_047274759.1 afadin isoform X16

UniProtKB/TrEMBL

H0Y8U8
XM_047418807.1 → XP_047274763.1 afadin isoform X20

UniProtKB/TrEMBL

H0Y8U8
XM_047418822.1 → XP_047274778.1 afadin isoform X38

UniProtKB/TrEMBL

G1UI22
XM_047418809.1 → XP_047274765.1 afadin isoform X22

UniProtKB/TrEMBL

H0Y8U8
XM_047418812.1 → XP_047274768.1 afadin isoform X25

UniProtKB/TrEMBL

H0Y8U8
XM_047418825.1 → XP_047274781.1 afadin isoform X42

UniProtKB/TrEMBL

G1UI22
XM_047418799.1 → XP_047274755.1 afadin isoform X12

UniProtKB/TrEMBL

H0Y8U8
XM_047418817.1 → XP_047274773.1 afadin isoform X33

UniProtKB/TrEMBL

G1UI22
XM_047418806.1 → XP_047274762.1 afadin isoform X19

UniProtKB/TrEMBL

H0Y8U8
XM_017010885.2 → XP_016866374.1 afadin isoform X40

UniProtKB/TrEMBL

G1UI22

Conserved Domains (5) summary

cd01781
Location:246 → 345

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 → 131

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

cd00060
Location:383 → 483

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:595 → 916

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:992 → 1074

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047418827.1 → XP_047274783.1 afadin isoform X44

UniProtKB/TrEMBL

G1UI22

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

169164770..169309528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054355465.1 → XP_054211440.1 afadin isoform X1

UniProtKB/TrEMBL

H0Y8U8
XM_054355466.1 → XP_054211441.1 afadin isoform X2

UniProtKB/TrEMBL

H0Y8U8
XM_054355491.1 → XP_054211466.1 afadin isoform X27

UniProtKB/TrEMBL

G1UI22
XM_054355509.1 → XP_054211484.1 afadin isoform X45

UniProtKB/TrEMBL

G1UI22
XM_054355467.1 → XP_054211442.1 afadin isoform X3

UniProtKB/TrEMBL

H0Y8U8
XM_054355468.1 → XP_054211443.1 afadin isoform X4

UniProtKB/TrEMBL

H0Y8U8
XM_054355492.1 → XP_054211467.1 afadin isoform X28

UniProtKB/TrEMBL

G1UI22
XM_054355469.1 → XP_054211444.1 afadin isoform X5

UniProtKB/TrEMBL

H0Y8U8
XM_054355470.1 → XP_054211445.1 afadin isoform X6

UniProtKB/TrEMBL

H0Y8U8
XM_054355493.1 → XP_054211468.1 afadin isoform X29

UniProtKB/TrEMBL

G1UI22
XM_054355471.1 → XP_054211446.1 afadin isoform X7

UniProtKB/TrEMBL

H0Y8U8
XM_054355495.1 → XP_054211470.1 afadin isoform X31

UniProtKB/TrEMBL

G1UI22
XM_054355473.1 → XP_054211448.1 afadin isoform X9

UniProtKB/TrEMBL

H0Y8U8
XM_054355475.1 → XP_054211450.1 afadin isoform X11

UniProtKB/TrEMBL

H0Y8U8
XM_054355477.1 → XP_054211452.1 afadin isoform X13

UniProtKB/TrEMBL

H0Y8U8
XM_054355498.1 → XP_054211473.1 afadin isoform X34

UniProtKB/TrEMBL

G1UI22
XM_054355478.1 → XP_054211453.1 afadin isoform X14

UniProtKB/TrEMBL

H0Y8U8
XM_054355481.1 → XP_054211456.1 afadin isoform X17

UniProtKB/TrEMBL

H0Y8U8
XM_054355501.1 → XP_054211476.1 afadin isoform X37

UniProtKB/TrEMBL

G1UI22
XM_054355482.1 → XP_054211457.1 afadin isoform X18

UniProtKB/TrEMBL

H0Y8U8
XM_054355488.1 → XP_054211463.1 afadin isoform X24

UniProtKB/TrEMBL

H0Y8U8
XM_054355505.1 → XP_054211480.1 afadin isoform X41

UniProtKB/TrEMBL

G1UI22
XM_054355494.1 → XP_054211469.1 afadin isoform X30

UniProtKB/TrEMBL

G1UI22
XM_054355474.1 → XP_054211449.1 afadin isoform X10

UniProtKB/TrEMBL

H0Y8U8
XM_054355496.1 → XP_054211471.1 afadin isoform X32

UniProtKB/TrEMBL

G1UI22
XM_054355500.1 → XP_054211475.1 afadin isoform X36

UniProtKB/TrEMBL

G1UI22
XM_054355479.1 → XP_054211454.1 afadin isoform X15

UniProtKB/TrEMBL

H0Y8U8
XM_054355485.1 → XP_054211460.1 afadin isoform X21

UniProtKB/TrEMBL

H0Y8U8
XM_054355503.1 → XP_054211478.1 afadin isoform X39

UniProtKB/TrEMBL

G1UI22
XM_054355487.1 → XP_054211462.1 afadin isoform X23

UniProtKB/TrEMBL

H0Y8U8
XM_054355490.1 → XP_054211465.1 afadin isoform X26

UniProtKB/TrEMBL

H0Y8U8
XM_054355507.1 → XP_054211482.1 afadin isoform X43

UniProtKB/TrEMBL

G1UI22
XM_054355472.1 → XP_054211447.1 afadin isoform X8

UniProtKB/TrEMBL

H0Y8U8
XM_054355499.1 → XP_054211474.1 afadin isoform X35

UniProtKB/TrEMBL

G1UI22
XM_054355480.1 → XP_054211455.1 afadin isoform X16

UniProtKB/TrEMBL

H0Y8U8
XM_054355484.1 → XP_054211459.1 afadin isoform X20

UniProtKB/TrEMBL

H0Y8U8
XM_054355502.1 → XP_054211477.1 afadin isoform X38

UniProtKB/TrEMBL

G1UI22
XM_054355486.1 → XP_054211461.1 afadin isoform X22

UniProtKB/TrEMBL

H0Y8U8
XM_054355489.1 → XP_054211464.1 afadin isoform X25

UniProtKB/TrEMBL

H0Y8U8
XM_054355506.1 → XP_054211481.1 afadin isoform X42

UniProtKB/TrEMBL

G1UI22
XM_054355476.1 → XP_054211451.1 afadin isoform X12

UniProtKB/TrEMBL

H0Y8U8
XM_054355497.1 → XP_054211472.1 afadin isoform X33

UniProtKB/TrEMBL

G1UI22
XM_054355483.1 → XP_054211458.1 afadin isoform X19

UniProtKB/TrEMBL

H0Y8U8
XM_054355504.1 → XP_054211479.1 afadin isoform X40

UniProtKB/TrEMBL

G1UI22
XM_054355508.1 → XP_054211483.1 afadin isoform X44

UniProtKB/TrEMBL

G1UI22

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001040001.1: Suppressed sequence

Description

NM_001040001.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
NM_005936.2: Suppressed sequence

Description

NM_005936.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.