IL5RA interleukin 5 receptor subunit alpha [Gallus gallus (chicken)] - Gene

Summary

Symbol: IL5RAprovided by CGNC
Full Name: interleukin 5 receptor subunit alphaprovided by CGNC
Primary source: CGNC:6262
See related: Ensembl:ENSGALG00010020457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	12	NC_052543.1 (18269804..18285446, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	12	NC_052584.1 (18308216..18323684, complement)

Chromosome 12 - NC_052543.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified a full-length cDNA encoding chicken IL-5R alpha-chain (chIL-5Ralpha). The deduced amino acid sequence showed 41-43% identity to mammalian homologues. It has four well-conserved cysteines and a WSXWS motif in the extracellular region, and a PPXP motif in the cytoplasmic region.
Title: Molecular cloning of chicken interleukin-5 receptor α-chain and analysis of its binding specificity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immunoglobulin mediated immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-5 receptor subunit alpha

Names: interleukin 5 receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256152.2 → NP_001243081.1 interleukin-5 receptor subunit alpha

Status: VALIDATED

Source sequence(s)

JAENSK010000252

UniProtKB/TrEMBL

G1UHB7, R4GKR1

Related

ENSGALP00010029247.1, ENSGALT00010049490.1

Conserved Domains (1) summary

pfam09240
Location:139 → 236

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

18269804..18285446 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015293144.4 → XP_015148630.1 interleukin-5 receptor subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8V0ZEG3, E1C261, G1UHB8

Related

ENSGALP00010029243.1, ENSGALT00010049483.1

Conserved Domains (1) summary

pfam09240
Location:139 → 236

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

18308216..18323684 complement

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GenBank, FASTA, Sequence Viewer (Graphics)