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    Igsf11 immunoglobulin superfamily, member 11 [ Mus musculus (house mouse) ]

    Gene ID: 207683, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Igsf11provided by MGI
    Official Full Name
    immunoglobulin superfamily, member 11provided by MGI
    Primary source
    MGI:MGI:2388477
    See related
    Ensembl:ENSMUSG00000022790 AllianceGenome:MGI:2388477
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Igsf13; BT-IgSF; 1700025L02Rik
    Summary
    Predicted to enable ionotropic glutamate receptor binding activity. Involved in positive regulation of long-term synaptic potentiation; regulation of presynapse assembly; and trans-synaptic signaling. Predicted to be located in excitatory synapse; plasma membrane; and postsynaptic density. Predicted to be active in cell-cell junction. Is expressed in several structures, including adrenal gland; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human IGSF11 (immunoglobulin superfamily member 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 19.9), kidney adult (RPKM 17.5) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Igsf11 in Genome Data Viewer
    Location:
    16 B4; 16 26.87 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38712840..38847521)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38892476..39027159)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40835 Neighboring gene STARR-seq mESC enhancer starr_40836 Neighboring gene testis expressed 55 Neighboring gene predicted gene 15802 Neighboring gene predicted gene, 22500 Neighboring gene predicted gene, 34258 Neighboring gene STARR-positive B cell enhancer mm9_chr16:39052733-39053034 Neighboring gene STARR-seq mESC enhancer starr_40838 Neighboring gene predicted gene, 36585 Neighboring gene predicted gene, 36742

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes. Kim GM, et al. Exp Mol Med, 2023 Dec. PMID 38036734, Free PMC Article
    2. Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test. Montag D, et al. PLoS One, 2023. PMID 36607983, Free PMC Article
    3. IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95. Kim H, et al. Bone Res, 2020. PMID 32047704, Free PMC Article
    4. Promotion of differentiation in developing mouse cerebellar granule cells by a cell adhesion molecule BT-IgSF. Higashine K, et al. Neurosci Lett, 2018 Nov 1. PMID 30176341
    5. Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis. Suzu S, et al. Biochem Biophys Res Commun, 2002 Sep 6. PMID 12207903

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes.
      Title: IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes.
    2. Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test.
      Title: Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test.
    3. IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene.
      Title: IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene.
    4. somatotrope neurosecretory hyperfunction in IGSF1-deficient humans and mice.
      Title: IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction.
    5. that BT-IgSF is one of the important cell adhesion molecules that regulate the developmentof mouse cerebellum
      Title: Promotion of differentiation in developing mouse cerebellar granule cells by a cell adhesion molecule BT-IgSF.
    6. Molecular cloning of BT-IgSF which is preferentially expressed by brain and testis
      Title: Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maintenance of protein location IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of protein location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mini excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mini excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trans-synaptic signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in trans-synaptic signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in excitatory synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 11
    Names
    brain and testis-specific immunoglobulin superfamily protein
    immunoglobulin superfamily, member 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_170599.2 → NP_733548.2  immunoglobulin superfamily member 11 precursor

      See identical proteins and their annotated locations for NP_733548.2

      Status: PROVISIONAL

      Source sequence(s)
      BC057555
      Consensus CDS
      CCDS28175.1
      UniProtKB/Swiss-Prot
      P0C673
      Related
      ENSMUSP00000023478.8, ENSMUST00000023478.8
      Conserved Domains (3) summary
      smart00410
      Location:157 → 232
      IG_like; Immunoglobulin like
      pfam07686
      Location:27 → 141
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:158 → 223
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      38712840..38847521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245851.2 → XP_011244153.1  immunoglobulin superfamily member 11 isoform X1

      See identical proteins and their annotated locations for XP_011244153.1

      UniProtKB/TrEMBL
      D3Z6S7
      Conserved Domains (3) summary
      pfam13927
      Location:88 → 160
      Ig_3; Immunoglobulin domain
      cd00096
      Location:13 → 18
      Ig; Ig strand C' [structural motif]
      cl11960
      Location:5 → 67
      Ig; Immunoglobulin domain

    2. XM_036159828.1 → XP_036015721.1  immunoglobulin superfamily member 11 isoform X1

      UniProtKB/TrEMBL
      D3Z6S7
      Related
      ENSMUSP00000110354.2, ENSMUST00000114706.8
      Conserved Domains (3) summary
      pfam13927
      Location:88 → 160
      Ig_3; Immunoglobulin domain
      cd00096
      Location:13 → 18
      Ig; Ig strand C' [structural motif]
      cl11960
      Location:5 → 67
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C673.1 GenPept UniProtKB/Swiss-Prot:P0C673

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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