U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Eno1 enolase 1, alpha non-neuron [ Mus musculus (house mouse) ]

    Gene ID: 13806, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eno1provided by MGI
    Official Full Name
    enolase 1, alpha non-neuronprovided by MGI
    Primary source
    MGI:MGI:95393
    See related
    Ensembl:ENSMUSG00000063524 AllianceGenome:MGI:95393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NNE; Eno-1; MBP-1
    Summary
    Enables RNA binding activity and phosphopyruvate hydratase activity. Involved in gluconeogenesis and glycolytic process. Acts upstream of or within cellular response to interleukin-7 and in utero embryonic development. Located in cell surface. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 310.6), subcutaneous fat pad adult (RPKM 285.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eno1 in Genome Data Viewer
    Location:
    4 E2; 4 81.24 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150321165..150333336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150236708..150248879)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52492 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 7 Neighboring gene STARR-seq mESC enhancer starr_12144 Neighboring gene carbonic anhydrase 6 Neighboring gene STARR-positive B cell enhancer ABC_E8035 Neighboring gene STARR-seq mESC enhancer starr_12148 Neighboring gene STARR-seq mESC enhancer starr_12150 Neighboring gene STARR-seq mESC enhancer starr_12151 Neighboring gene predicted gene, 33415 Neighboring gene arginine glutamic acid dipeptide (RE) repeats Neighboring gene small nuclear ribonucleoprotein F

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103111, MGC107267

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphopyruvate hydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphopyruvate hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphopyruvate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to acid chemical IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of phosphopyruvate hydratase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-enolase
    Names
    2-phospho-D-glycerate hydro-lyase
    2-phospho-D-glycerate hydrolase
    c-Myc promoter binding protein
    non-neural enolase
    NP_001366056.1
    NP_001366057.1
    NP_075608.2
    XP_036019540.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379127.2NP_001366056.1  alpha-enolase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606903
      UniProtKB/TrEMBL
      Q6PHC1
      Conserved Domains (1) summary
      PLN00191
      Location:2432
      PLN00191; enolase
    2. NM_001379128.1NP_001366057.1  alpha-enolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606903
      UniProtKB/Swiss-Prot
      P17182, Q99KT7, Q9DCY7
      UniProtKB/TrEMBL
      Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
      Conserved Domains (1) summary
      PLN00191
      Location:2432
      PLN00191; enolase
    3. NM_001429235.1NP_001416164.1  alpha-enolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606903
      UniProtKB/Swiss-Prot
      P17182, Q99KT7, Q9DCY7
      UniProtKB/TrEMBL
      Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
    4. NM_001429236.1NP_001416165.1  alpha-enolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606903
      UniProtKB/Swiss-Prot
      P17182, Q99KT7, Q9DCY7
      UniProtKB/TrEMBL
      Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
    5. NM_001429237.1NP_001416166.1  alpha-enolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606903
      UniProtKB/Swiss-Prot
      P17182, Q99KT7, Q9DCY7
      UniProtKB/TrEMBL
      Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
    6. NM_001429238.1NP_001416167.1  alpha-enolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606903
      UniProtKB/Swiss-Prot
      P17182, Q99KT7, Q9DCY7
      UniProtKB/TrEMBL
      Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
    7. NM_001429250.1NP_001416179.1  alpha-enolase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606903
      UniProtKB/TrEMBL
      Q6PHC1
    8. NM_023119.3NP_075608.2  alpha-enolase isoform 2

      See identical proteins and their annotated locations for NP_075608.2

      Status: VALIDATED

      Source sequence(s)
      AL606903
      Consensus CDS
      CCDS18971.1
      UniProtKB/Swiss-Prot
      P17182, Q99KT7, Q9DCY7
      UniProtKB/TrEMBL
      Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
      Related
      ENSMUSP00000079727.7, ENSMUST00000080926.13
      Conserved Domains (1) summary
      PLN00191
      Location:2432
      PLN00191; enolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      150321165..150333336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163647.1XP_036019540.1  alpha-enolase isoform X1

      UniProtKB/TrEMBL
      Q6PHC1
      Conserved Domains (1) summary
      PLN00191
      Location:2432
      PLN00191; enolase