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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001253738.1 → NP_001240667.1 tropomyosin alpha-3 chain isoform Tpm3.1cy
See identical proteins and their annotated locations for NP_001240667.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (3, also known as variant Tpm3.1) represents the use of an alternate promoter and differs in the 5' structure, causing translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.1cy, also known as isoform 3) has a distinct N-terminus and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
- Source sequence(s)
-
AK146557, BY284672, BY622941
- Consensus CDS
-
CCDS57223.1
- UniProtKB/TrEMBL
- D3Z2H9, Q58E70
- Related
- ENSMUSP00000029549.9, ENSMUST00000029549.16
- Conserved Domains (1) summary
-
- pfam00261
Location:12 → 246
- Tropomyosin; Tropomyosin
-
NM_001253740.1 → NP_001240669.1 tropomyosin alpha-3 chain isoform Tpm3.2cy
See identical proteins and their annotated locations for NP_001240669.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (4, also known as variant Tpm3.2) represents the use of an alternate promoter and has multiple differences compared to variant Tpm3.13. These differences result in a different 5' UTR and cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.2cy, also known as isoform 4) has a distinct N-terminus and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
- Source sequence(s)
-
AK146557, BY284672, BY622941, CX237327
- UniProtKB/TrEMBL
-
Q58E70
- Conserved Domains (2) summary
-
- pfam00261
Location:12 → 246
- Tropomyosin; Tropomyosin
- pfam06009
Location:150 → 229
- Laminin_II; Laminin Domain II
-
NM_001271764.2 → NP_001258693.1 tropomyosin alpha-3 chain isoform Tpm3.5cy
See identical proteins and their annotated locations for NP_001258693.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (5, also known as variant Tpm3.5) represents the use of an alternate promoter and has multiple differences compared to variant Tpm3.13. These differences result in different 5' and 3' UTRs and cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.5cy, also known as isoform 5) has distinct N- and C- termini and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
- Source sequence(s)
-
AI842950, AK050665, BB690682, BY284672
- UniProtKB/TrEMBL
-
Q8C7C3
- Conserved Domains (1) summary
-
- pfam00261
Location:12 → 246
- Tropomyosin
-
NM_001293748.1 → NP_001280677.2 tropomyosin alpha-3 chain isoform Tpm3.12st
See identical proteins and their annotated locations for NP_001280677.2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2, also known as variant Tpm3.12) differs in the 3' UTR and has multiple differences in the 3' coding region compared to variant Tpm3.13. The encoded isoform (Tpm3.12st, also known as isoform 2) is the same length as isoform Tpm3.13cy, but contains a distinct C-terminal segment. The encoded protein is the fast skeletal muscle isoform.
- Source sequence(s)
-
AC163616
- UniProtKB/Swiss-Prot
- P21107, Q09021, Q60606, Q80SW6, Q9EPW3
- Related
- ENSMUSP00000113578.2, ENSMUST00000121503.8
- Conserved Domains (2) summary
-
- pfam00261
Location:49 → 283
- Tropomyosin
- pfam16526
Location:14 → 73
- CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
-
NM_001293749.1 → NP_001280678.1 tropomyosin alpha-3 chain isoform Tpm3.4cy
Status: VALIDATED
- Description
- Transcript Variant: This variant (6, also known as variant Tpm3.4) represents the use of an alternate promoter, differs in the 5' and 3' structures and has multiple differences in the coding region compared to variant Tpm3.13. These differences cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.4cy, also known as isoform 6) has distinct N- and C- termini and is shorter than isoform Tpm3.13cy.
- Source sequence(s)
-
AC163616, BF464045
- Consensus CDS
-
CCDS79961.1
- UniProtKB/TrEMBL
-
D3Z6I8
- Related
- ENSMUSP00000113219.2, ENSMUST00000119158.8
- Conserved Domains (1) summary
-
- pfam00261
Location:12 → 245
- Tropomyosin; Tropomyosin
-
NM_001357581.1 → NP_001344510.1 tropomyosin alpha-3 chain isoform Tpm3.3cy
Status: VALIDATED
- Source sequence(s)
-
AC163616, AI842950
- Consensus CDS
-
CCDS89659.1
- UniProtKB/TrEMBL
-
E9Q7Q3
- Related
- ENSMUSP00000113056.2, ENSMUST00000118566.8
- Conserved Domains (1) summary
-
- pfam00261
Location:12 → 246
- Tropomyosin
-
NM_022314.3 → NP_071709.3 tropomyosin alpha-3 chain isoform Tpm3.13cy
See identical proteins and their annotated locations for NP_071709.3
Status: VALIDATED
- Description
- Transcript Variant: This variant (1, also known as variant Tpm3.13) encodes isoform Tpm3.13cy (also known as isoform 1). This isoform is the same length as isoform Tpm3.12st, but contains a distinct C-terminal segment.
- Source sequence(s)
-
AK146557, BC029186, BY622941, BY770803
- Consensus CDS
-
CCDS38499.2
- UniProtKB/TrEMBL
-
E9Q5J9
- Related
- ENSMUSP00000113978.2, ENSMUST00000119570.8
- Conserved Domains (1) summary
-
- pfam00261
Location:49 → 283
- Tropomyosin